HO-PEG8-CH2COOH

Name: HO-PEG8-CH2COOH
Brand: TargetMol
SKU: T18017
Rating: 4.5 (1 reviews)

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Catalog No. T18017Cas No. 780006-30-6

HO-PEG8-CH2COOH, a PEG-based linker for PROTACs, unites two essential ligands critical for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

HO-PEG8-CH2COOH

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Catalog No. T18017Cas No. 780006-30-6

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Product Introduction

Bioactivity

Description	HO-PEG8-CH2COOH, a PEG-based linker for PROTACs, unites two essential ligands critical for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.
In vitro	PROTACs, comprising two distinct ligands linked by a connector—one binding an E3 ubiquitin ligase and the other targeting a specific protein—utilize the intracellular ubiquitin-proteasome system for the selective degradation of target proteins[1].

Chemical Properties

Molecular Weight	428.47
Formula	C₁₈H₃₆O₁₁
Cas No.	780006-30-6
Relative Density.	1.162 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc