Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Daun02

Name: Daun02
Brand: TargetMol
SKU: T15054
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T15054Cas No. 290304-24-4

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

Daun02

😃Good

Catalog No. T15054Cas No. 290304-24-4

Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$747	7-10 days	7-10 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.
In vitro	Daun02 is converted by β-galactosidase to Daunorubicin, which has been shown to reduce Ca2+-dependent action potentials in neuroblastoma cells [1]. Daun02 is a good substrate for β-galactosidase (β-gal) and it also is a topoisomerase inhibitor [2]. The concentration of Daun02 producing 50% (EC50) decrease in cell viability is 0.5 μM, 1.5 μM, and 3.5 μM for T47-D, Panc02, and MCF-7, respectively [3].
In vivo	Daun02 is an efficient substrate for β-gal (Km: 0.37 mM; Vmax: 8.6 μmol/min/mg). It demonstrates 79% plasma protein binding, compared to 94% for Daunomycin at 10 μM [3].

Chemical Properties

Molecular Weight	884.79
Formula	C₄₁H₄₄N₂O₂₀
Cas No.	290304-24-4
Smiles	COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](NC(=O)OCc6ccc(O[C@@H]7O[C@H](CO)[C@H](O)[C@H](O)[C@H]7O)c(c6)[N+]([O-])=O)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O
Relative Density.	1.67 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (113.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.73 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1302 mL	5.6511 mL	11.3021 mL	56.5106 mL
5 mM	0.2260 mL	1.1302 mL	2.2604 mL	11.3021 mL
10 mM	0.1130 mL	0.5651 mL	1.1302 mL	5.6511 mL
20 mM	0.0565 mL	0.2826 mL	0.5651 mL	2.8255 mL
50 mM	0.0226 mL	0.1130 mL	0.2260 mL	1.1302 mL
100 mM	0.0113 mL	0.0565 mL	0.1130 mL	0.5651 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc