PROTAC K-Ras Degrader-4

Name: PROTAC K-Ras Degrader-4
Brand: TargetMol
SKU: T206045
Rating: 4.5 (1 reviews)

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Catalog No. T206045Cas No. 2938169-99-2

PROTAC K-Ras Degrader-4 (Compound 4) is a proteolysis-targeting chimera (PROTAC) molecule designed to selectively degrade oncogenic mutants of K-Ras, effectively degrading KRASG12D in the GP5d cell line and KRASG12V in SW620 cells with DC50 of 1 nM and 13 nM, respectively; it concomitantly inhibits the downstream MAPK signaling pathway and represents a novel therapeutic strategy for cancer research targeting previously undruggable Ras mutations.

PROTAC K-Ras Degrader-4

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Catalog No. T206045Cas No. 2938169-99-2

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Product Introduction

Bioactivity

Description

In vitro

PROTAC K-Ras Degrader-4 (0-1 μM, 5 days) was used to treat GP2d cell lines and was found to inhibit the expression of DUSP6 and the proliferation of GP2d cells with KRASG12D mutation. [1]

Chemical Properties

Molecular Weight	989.22
Formula	C₅₀H₆₀N₁₂O₆S₂
Cas No.	2938169-99-2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (80.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0109 mL	5.0545 mL	10.1090 mL	50.5449 mL
5 mM	0.2022 mL	1.0109 mL	2.0218 mL	10.1090 mL
10 mM	0.1011 mL	0.5054 mL	1.0109 mL	5.0545 mL
20 mM	0.0505 mL	0.2527 mL	0.5054 mL	2.5272 mL
50 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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