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BCL6-IN-6
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Catalog No. T60008Cas No. 2408882-54-0
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.
BCL6-IN-6
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Purity: 98.90%
Catalog No. T60008Cas No. 2408882-54-0
BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | In Stock | In Stock | |
| 5 mg | $103 | In Stock | In Stock | |
| 10 mg | $179 | In Stock | In Stock | |
| 25 mg | $285 | In Stock | In Stock | |
| 50 mg | $407 | In Stock | In Stock | |
| 100 mg | $547 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.90%
Appearance:Solid
Color:Yellow
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Product Introduction
BCL6-IN-6 AI Summary
BCL6-IN-6 exhibits significant bioactivities, including inhibition of recombinant human C-terminal GST-tagged BCL6 BTB domain with an IC50 of 470.0 nM and showing binding affinity to the human BCL6 BTB domain. It demonstrates antiproliferative activity across various human cell lines, with IC50 values between 920.0 nM to 3250.0 nM, as well as cytotoxicity with IC50 values ranging from 8130.0 nM to 32400.0 nM. Additionally, it induces apoptosis in SUDHL4 cells, displaying both early and late apoptotic effects at varying concentrations. In vivo, it inhibits germinal center formation in NP-CGG immunized C57BL/6 mice, affecting splenic GC B cells and the proportion of Tfh cells at a 10 mg/kg dose. The compound shows antiproliferative and antitumor activity against BCL-6 dependent human SU-DHL-4 cells, including those xenografted in mice, and results in increased mRNA expression of CD69, CXCR4, and ATR. Furthermore, BCL6-IN-6 is metabolically stable in human liver microsomes with a half-life greater than 1.0 hour and demonstrates high protein binding in human plasma, with a fraction unbound of 0.076..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes. |
| Molecular Weight | 522.64 |
| Formula | C27H31FN6O2S |
| Cas No. | 2408882-54-0 |
| Smiles | COc1cc(Nc2nc(ncc2F)N2C[C@H](C)N[C@H](C)C2)ccc1NC(=O)c1ccc(s1)C1=CCCC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: < 5.23 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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