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LCL521 dihydrochloride is a dual inhibitor of acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase). By targeting these lysosomal enzymes, LCL521 dihydrochloride modulates sphingolipid metabolism, with potential applications in cancer and metabolic disorder research.

| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $2,190 | 6-8 weeks |
| Description | LCL521 dihydrochloride is a dual inhibitor of acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase). By targeting these lysosomal enzymes, LCL521 dihydrochloride modulates sphingolipid metabolism, with potential applications in cancer and metabolic disorder research. |
| In vitro | LCL521 dihydrochloride is a potent cellular ACDase inhibitor at a concentration of 1 µM. At a higher concentration (10 µM), LCL521 dihydrochloride additionally exerts a reducing effect on the α-form of ACDase. Specifically, in MCF7 cells, LCL521 dihydrochloride (10 µM) induces a time-dependent decrease in the α-ACDase form, which is observable within 1 to 5 hours.[1] |
| Synonyms | LCL 521 dihydrochloride, 1,3DMG-B13 dihydrochloride |
| Molecular Weight | 665.69 |
| Formula | C31H54Cl2N4O7 |
| Cas No. | 1226759-47-2 |
| Smiles | CCCCCCCCCCCCCC(N[C@H](COC(CN(C)C)=O)[C@@H](C1=CC=C(C=C1)[N+]([O-])=O)OC(CN(C)C)=O)=O.Cl.Cl |
| Relative Density. | 1.31g/cm3 |
| Color | White |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 20 mg/mL (30.04 mM), Sonication is recommended. DMSO: 80 mg/mL (120.18 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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