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LCL521 dihydrochloride

Name: LCL521 dihydrochloride
Brand: TargetMol
SKU: T11835L
Rating: 4.5 (1 reviews)

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Catalog No. T11835LCas No. 1226759-47-2

Alias LCL 521 dihydrochloride, 1,3DMG-B13 dihydrochloride

LCL521 dihydrochloride is a dual inhibitor of acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase). By targeting these lysosomal enzymes, LCL521 dihydrochloride modulates sphingolipid metabolism, with potential applications in cancer and metabolic disorder research.

LCL521 dihydrochloride

😃Good

Catalog No. T11835LAlias LCL 521 dihydrochloride, 1,3DMG-B13 dihydrochlorideCas No. 1226759-47-2

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$987	6-8 weeks	6-8 weeks
50 mg	$1,360	6-8 weeks	6-8 weeks
100 mg	$2,190	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	LCL521 dihydrochloride is a dual inhibitor of acid ceramidase (ACDase) and lysosomal acid sphingomyelinase (ASMase). By targeting these lysosomal enzymes, LCL521 dihydrochloride modulates sphingolipid metabolism, with potential applications in cancer and metabolic disorder research.
In vitro	LCL521 dihydrochloride is a potent cellular ACDase inhibitor at a concentration of 1 µM. At a higher concentration (10 µM), LCL521 dihydrochloride additionally exerts a reducing effect on the α-form of ACDase. Specifically, in MCF7 cells, LCL521 dihydrochloride (10 µM) induces a time-dependent decrease in the α-ACDase form, which is observable within 1 to 5 hours.[1]
Synonyms	LCL 521 dihydrochloride, 1,3DMG-B13 dihydrochloride

Chemical Properties

Molecular Weight	665.69
Formula	C₃₁H₅₄Cl₂N₄O₇
Cas No.	1226759-47-2
Smiles	CCCCCCCCCCCCCC(N[C@H](COC(CN(C)C)=O)[C@@H](C1=CC=C(C=C1)[N+]([O-])=O)OC(CN(C)C)=O)=O.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 20 mg/mL (30.04 mM), Sonication is recommended.

DMSO: 80 mg/mL (120.18 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5022 mL	7.5110 mL	15.0220 mL	75.1100 mL
5 mM	0.3004 mL	1.5022 mL	3.0044 mL	15.0220 mL
10 mM	0.1502 mL	0.7511 mL	1.5022 mL	7.5110 mL
20 mM	0.0751 mL	0.3756 mL	0.7511 mL	3.7555 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0300 mL	0.1502 mL	0.3004 mL	1.5022 mL
100 mM	0.0150 mL	0.0751 mL	0.1502 mL	0.7511 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc