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AZ13705339

Name: AZ13705339
Brand: TargetMol
SKU: T26704
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26704Cas No. 2016806-57-6

Alias AZ-13705339, AZ 13705339

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

AZ13705339

🥰Excellent

Purity: 99.77%

Catalog No. T26704Alias AZ-13705339, AZ 13705339Cas No. 2016806-57-6

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$222	In Stock
50 mg	$355	In Stock
100 mg	$572	In Stock

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Purity:99.77%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.
Targets&IC50	PAK1:0.33 nM, PAK1:0.28 nM (Kd), pPAK1:59 nM, PAK2:0.32 nM (Kd)
In vitro	AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death[2]. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion[3].
In vivo	In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM[1].
Synonyms	AZ-13705339, AZ 13705339

Chemical Properties

Molecular Weight	629.75
Formula	C₃₃H₃₆FN₇O₃S
Cas No.	2016806-57-6
Smiles	CCS(=O)(=O)c1cc(Nc2ncc(F)c(n2)N(Cc2ccccc2C#N)c2cc(CO)ccc2C)ccc1N1CCN(C)CC1
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (357.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5879 mL	7.9397 mL	15.8793 mL	79.3966 mL
5 mM	0.3176 mL	1.5879 mL	3.1759 mL	15.8793 mL
10 mM	0.1588 mL	0.7940 mL	1.5879 mL	7.9397 mL
20 mM	0.0794 mL	0.3970 mL	0.7940 mL	3.9698 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5879 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc