Pomalidomide-amino-PEG4-NH2

Name: Pomalidomide-amino-PEG4-NH2
Brand: TargetMol
SKU: T39866
Rating: 4.5 (1 reviews)

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Catalog No. T39866Cas No. 2331259-44-8

Alias Pomalidomide-amino-PEG4-NH2

Pomalidomide-amino-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand with a linker, used in PROTAC technology.

Pomalidomide-amino-PEG4-NH2

😃Good

Catalog No. T39866Alias Pomalidomide-amino-PEG4-NH2Cas No. 2331259-44-8

Pomalidomide-amino-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand with a linker, used in PROTAC technology.

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Product Introduction

Bioactivity

Description	Pomalidomide-amino-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that combines the Pomalidomide-based cereblon ligand with a linker, used in PROTAC technology.
In vitro	PROTACs consist of two distinct ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets a specific protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
Synonyms	Pomalidomide-amino-PEG4-NH2

Chemical Properties

Molecular Weight	506.512
Formula	C₂₃H₃₀N₄O₉
Cas No.	2331259-44-8
Smiles	NCCOCCOCCOCCOCC(=O)Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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