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Ro 41-5253

Name: Ro 41-5253
Brand: TargetMol
SKU: T28589
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28589Cas No. 144092-31-9

Alias Ro-41-5253, Ro 415253

Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells.

Ro 41-5253

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Purity: 98%

Catalog No. T28589Alias Ro-41-5253, Ro 415253Cas No. 144092-31-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$52	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Ro 41-5253 is an orally active RARα antagonist, ligand, and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity, inhibits proliferation, and induces apoptosis in MCF-7 and ZR-75.1 estrogen receptor-positive breast cancer cells.
Targets&IC50	RARα:60 nM, RARγ:3.3 μM, RARβ:2.4 μM
In vitro	In human breast cancer cell lines MCF-7 and ZR 75.1, Ro 41-5253 (1 nM-10 μM; for 10 days) inhibited cell growth. At a concentration of 10 μM, the inhibition rate of MCF-7 cell growth was 81%, 30% at 1 μM, and no significant inhibition was observed at concentrations below 0.1 μM. For ZR 75.1 cells, the growth inhibition rate was 74% at 10 μM, 63% at 1 μM, and 42% at 0.1 μM[1].
In vivo	In six-week-old athymic female Balb/c mice implanted with MCF-7 cell line, Ro 41-5253 (10, 30, 100, 300, and 600 mg/kg; oral gavage; once weekly; for 4 weeks) resulted in a reduction in tumor volume at doses of 10, 30, and 100 mg/kg, with no toxic side effects[2].
Synonyms	Ro-41-5253, Ro 415253

Chemical Properties

Molecular Weight	484.65
Formula	C₂₈H₃₆O₅S
Cas No.	144092-31-9
Smiles	CCCCCCCOc1cc2c(cc1\C(C)=C\c1ccc(cc1)C(O)=O)C(C)(C)CCS2(=O)=O
Relative Density.	1.154g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (165.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0633 mL	10.3167 mL	20.6334 mL	103.1672 mL
5 mM	0.4127 mL	2.0633 mL	4.1267 mL	20.6334 mL
10 mM	0.2063 mL	1.0317 mL	2.0633 mL	10.3167 mL
20 mM	0.1032 mL	0.5158 mL	1.0317 mL	5.1584 mL
50 mM	0.0413 mL	0.2063 mL	0.4127 mL	2.0633 mL
100 mM	0.0206 mL	0.1032 mL	0.2063 mL	1.0317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc