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Raptinal
🥰Excellent
Catalog No. T38563Cas No. 1176-09-6
Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
Raptinal
🥰Excellent
Catalog No. T38563Cas No. 1176-09-6
Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $115 | In Stock | |
| 25 mg | $189 | In Stock | |
| 50 mg | $279 | In Stock | |
| 100 mg | $413 | In Stock | |
| 200 mg | $615 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $89 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines. |
| In vitro | In human gastric cancer cell lines AGS, MKN28, and MKN45, Raptinal(10 μM) induces the cleavage of pro-caspase-3 into the active form. Raptinal induces death against various cancer and non-cancerous cell lines (IC50 = 0.7-3.4 μM)[2]. |
| In vivo | In B16-F10 and 4T1 models, intraperitoneal administration of Raptinal (20 mg/kg) exerts anticancer activity. In C57BL/6 mice, intravenous administration of Raptinal (37.5 mg/kg) shows the peak plasma concentration and elimination half-life of 54.40.9 μg/mL and 92.1 minutes, respectively[2]. |
| Molecular Weight | 386.44 |
| Formula | C28H18O2 |
| Cas No. | 1176-09-6 |
| Smiles | O=CC1(c2ccccc2-c2ccccc12)C1(C=O)c2ccccc2-c2ccccc12 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 18.0 mg/mL (46.6 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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