store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 89.00 |
Description | Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines. |
In vitro | In human gastric cancer cell lines AGS, MKN28, and MKN45, Raptinal(10 μM) induces the cleavage of pro-caspase-3 into the active form. Raptinal induces death against various cancer and non-cancerous cell lines (IC50 = 0.7-3.4 μM)[2]. |
In vivo | In B16-F10 and 4T1 models, intraperitoneal administration of Raptinal (20 mg/kg) exerts anticancer activity. In C57BL/6 mice, intravenous administration of Raptinal (37.5 mg/kg) shows the peak plasma concentration and elimination half-life of 54.40.9 μg/mL and 92.1 minutes, respectively[2]. |
Molecular Weight | 386.44 |
Formula | C28H18O2 |
CAS No. | 1176-09-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 18.0 mg/mL (46.6 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Raptinal 1176-09-6 Apoptosis Proteases/Proteasome Caspase inhibitor inhibit