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PT-262

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Catalog No. T28469Cas No. 86811-36-1
Alias PT262, PT 262

PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.

PT-262

PT-262

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Catalog No. T28469Alias PT262, PT 262Cas No. 86811-36-1
PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$535 days5 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Targets&IC50
ROCK:5 μM
In vitro
In A549 lung carcinoma cells, treatment with PT-262 (5-40 μM) inhibited proliferation and promoted G2/M phase arrest by inhibiting CDC2 and ERK phosphorylation. It also triggered mitochondrial dysfunction and Caspase-3 activation, leading to apoptosis [1].
SynonymsPT262, PT 262
Chemical Properties
Molecular Weight276.72
FormulaC14H13ClN2O2
Cas No.86811-36-1
SmilesO=C1C(Cl)=C(C(=O)C2=CC=CN=C12)N3CCCCC3
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (289.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6138 mL18.0688 mL36.1376 mL180.6881 mL
5 mM0.7228 mL3.6138 mL7.2275 mL36.1376 mL
10 mM0.3614 mL1.8069 mL3.6138 mL18.0688 mL
20 mM0.1807 mL0.9034 mL1.8069 mL9.0344 mL
50 mM0.0723 mL0.3614 mL0.7228 mL3.6138 mL
100 mM0.0361 mL0.1807 mL0.3614 mL1.8069 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PT-262
Related Tags: buy PT-262 | purchase PT-262 | PT-262 cost | order PT-262 | PT-262 chemical structure | PT-262 in vitro | PT-262 formula | PT-262 molecular weight
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