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PT-262 (Synonyms: PT262, PT 262)

Name: PT-262
Brand: TargetMol
SKU: T28469
Rating: 4.5 (1 reviews)

Catalog No. T28469 Copy Product Info

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PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.

PT-262

Copy Product Info

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Catalog No. T28469

Synonyms PT262, PT 262

Cas No. 86811-36-1

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$53	5 days	5 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Targets&IC50	ROCK:5 μM
In vitro	In A549 lung carcinoma cells, treatment with PT-262 (5-40 μM) inhibited proliferation and promoted G2/M phase arrest by inhibiting CDC2 and ERK phosphorylation. It also triggered mitochondrial dysfunction and Caspase-3 activation, leading to apoptosis [1].
Synonyms	PT262, PT 262

Chemical Properties

Molecular Weight	276.72
Formula	C₁₄H₁₃ClN₂O₂
Cas No.	86811-36-1
Smiles	O=C1C(Cl)=C(C(=O)C2=CC=CN=C12)N3CCCCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (289.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6138 mL	18.0688 mL	36.1376 mL	180.6881 mL
5 mM	0.7228 mL	3.6138 mL	7.2275 mL	36.1376 mL
10 mM	0.3614 mL	1.8069 mL	3.6138 mL	18.0688 mL
20 mM	0.1807 mL	0.9034 mL	1.8069 mL	9.0344 mL
50 mM	0.0723 mL	0.3614 mL	0.7228 mL	3.6138 mL
100 mM	0.0361 mL	0.1807 mL	0.3614 mL	1.8069 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc