Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

PT-262

😃Good
Catalog No. T28469Cas No. 86811-36-1
Alias PT262, PT 262

PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.

PT-262

PT-262

😃Good
Catalog No. T28469Alias PT262, PT 262Cas No. 86811-36-1
PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$535 days5 days
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Resource Download

Product Introduction

Bioactivity
Description
PT-262 is a potent Rho-associated protein kinase (ROCK) inhibitor with an IC50 value of approximately 5 μM, and it induces mitochondrial membrane potential loss, enhances caspase-3 activation, and promotes apoptosis, while concurrently inhibiting ERK and CDC2 phosphorylation through a p53-independent signaling pathway, disrupting cytoskeletal organization and cell migration, and collectively exerting broad anticancer activity that makes PT-262 a valuable tool for mechanistic cancer biology and signal transduction research.
Targets&IC50
ROCK:5 μM
In vitro
In A549 lung carcinoma cells, treatment with PT-262 (5-40 μM) inhibited proliferation and promoted G2/M phase arrest by inhibiting CDC2 and ERK phosphorylation. It also triggered mitochondrial dysfunction and Caspase-3 activation, leading to apoptosis [1].
SynonymsPT262, PT 262
Chemical Properties
Molecular Weight276.72
FormulaC14H13ClN2O2
Cas No.86811-36-1
SmilesO=C1C(Cl)=C(C(=O)C2=CC=CN=C12)N3CCCCC3
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (289.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6138 mL18.0688 mL36.1376 mL180.6881 mL
5 mM0.7228 mL3.6138 mL7.2275 mL36.1376 mL
10 mM0.3614 mL1.8069 mL3.6138 mL18.0688 mL
20 mM0.1807 mL0.9034 mL1.8069 mL9.0344 mL
50 mM0.0723 mL0.3614 mL0.7228 mL3.6138 mL
100 mM0.0361 mL0.1807 mL0.3614 mL1.8069 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PT-262
Related Tags: buy PT-262 | purchase PT-262 | PT-262 cost | order PT-262 | PT-262 chemical structure | PT-262 in vitro | PT-262 formula | PT-262 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.