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Semapimod tetrahydrochloride

🥰Excellent
Catalog No. T35593Cas No. 164301-51-3
Alias CPSI-2364 tetrahydrochloride

Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.

Semapimod tetrahydrochloride
Other Forms of Semapimod tetrahydrochloride:

Semapimod tetrahydrochloride

🥰Excellent
Purity: 99.8%
Catalog No. T35593Alias CPSI-2364 tetrahydrochlorideCas No. 164301-51-3
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$68In StockIn Stock
5 mg$157In StockIn Stock
10 mg$269-In Stock
25 mg$456-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.8%
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Product Introduction

Bioactivity
Description
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine production inhibitor that interferes with macrophage and microglia function. Sematimod tetrahydrochloride inhibits TLR4 signaling, TNF-α, IL-1β, and IL-6, and is used in the study of Crohn's disease and other inflammatory conditions.
In vivo
In male OZ rats, Semapimod tetrahydrochloride (5 mg/kg; i.p.; once daily for 2 weeks) restored endothelium-dependent vasorelaxation[1].
SynonymsCPSI-2364 tetrahydrochloride
Chemical Properties
Molecular Weight890.74
FormulaC34H56Cl4N18O2
Cas No.164301-51-3
SmilesCl.Cl.Cl.Cl.C\C(=N/NC(N)=N)c1cc(NC(=O)CCCCCCCCC(=O)Nc2cc(cc(c2)C(\C)=N\NC(N)=N)C(\C)=N\NC(N)=N)cc(c1)C(\C)=N\NC(N)=N
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 1 mg/mL (1.12 mM), Sonication is recommended.
H2O: 1 mg/mL (1.12 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.1227 mL5.6133 mL11.2266 mL56.1331 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

TLR6TLR4SemapimodMAPK
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