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Ivacaftor-D9 (Synonyms: VX-770-d9, deutivacaftor, CTP-656)

Name: Ivacaftor-D9
Brand: TargetMol
SKU: T27098
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T27098 Copy Product Info

Purity: 99.13%

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Ivacaftor-D9 is transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.

Ivacaftor-D9

Copy Product Info

🥰Excellent

Catalog No. T27098

Synonyms VX-770-d9, deutivacaftor, CTP-656

Ivacaftor-D9 is transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.

Cas No. 1413431-07-8

Pack Size	Price	USA Stock	Global Stock
1 mg	$123	-	In Stock
5 mg	$297	-	In Stock
10 mg	$519	-	In Stock
25 mg	$832	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.13%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ivacaftor-D9 is transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.
Targets&IC50	CFTR:255 nM (EC50)
In vivo	In pharmacokinetic studies, male Sprague‑Dawley rats exhibited favorable pharmacokinetic profiles following a single oral dose of 10 mg/kg Ivacaftor-D9. Plasma drug concentrations were monitored for 72 hours, with the main parameters as follows: Cmax 1970 ng/mL (CV 15%), AUC₀₋₂₄h 24260 h·ng/mL (CV 17%), C₂₄h 413 ng/mL (CV 19%), and t₁/₂ 13.9 h. In male beagle dogs, following a single oral dose of 3 mg/kg Ivacaftor-D9, the corresponding pharmacokinetic parameters were: Cmax 3643 ng/mL (CV 9%), AUC₀₋₂₄h 49782 h·ng/mL (CV 31%), C₂₄h 1418 ng/mL (CV 31%), and t₁/₂ 22.8 h.
Synonyms	VX-770-d9, deutivacaftor, CTP-656

Chemical Properties

Molecular Weight	401.55
Formula	C₂₄H₁₉D₉N₂O₃
Cas No.	1413431-07-8
Smiles	C(C)(C)(C)C1=C(NC(=O)C=2C(=O)C=3C(NC2)=CC=CC3)C=C(O)C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (99.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4903 mL	12.4517 mL	24.9035 mL	124.5175 mL
5 mM	0.4981 mL	2.4903 mL	4.9807 mL	24.9035 mL
10 mM	0.2490 mL	1.2452 mL	2.4903 mL	12.4517 mL
20 mM	0.1245 mL	0.6226 mL	1.2452 mL	6.2259 mL
50 mM	0.0498 mL	0.2490 mL	0.4981 mL	2.4903 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc