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TEAD-IN-11

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Catalog No. T87984Cas No. 3032196-88-3

TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research.

TEAD-IN-11

TEAD-IN-11

😃Good
Catalog No. T87984Cas No. 3032196-88-3
TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5204-6 weeks4-6 weeks
50 mg$1,9804-6 weeks4-6 weeks
100 mg$2,5004-6 weeks4-6 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1 (IC 50 = 8.7 nM), TEAD2 (IC 50 = 3.4 nM), and TEAD3 (IC 50 = 5.6 nM), demonstrating selectivity for these isoforms as a covalent inhibitor. This compound is valuable for cancer research.
Targets&IC50
TEAD1:8.7 nM, TEAD2:3.4 nM, TEAD3:5.6 nM
In vitro
TEAD-IN-11 exhibits a strong inhibitory effect on MCF-7 reporter gene assays (IC 50 ≤10 nM) [1]. It demonstrates excellent selectivity for TEAD1 and TEAD2, achieving 93% and 95% inhibition respectively in HEK293T cells [1].
Chemical Properties
Molecular Weight293.28
FormulaC16H14F3NO
Cas No.3032196-88-3
SmilesO=C(C=C)N1CCC(C#CC2=CC=C(C=C2)C(F)(F)F)C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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