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TEAD-IN-11

Name: TEAD-IN-11
Brand: TargetMol
SKU: T87984
Rating: 4.5 (1 reviews)

(Synonyms: TEAD IN 11) Copy Product Info

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Synonyms: TEAD IN 11

Catalog No. T87984 Copy Product Info

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TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1, TEAD2, and TEAD3, with IC50 values of 8.7, 3.4, and 5.6 nM, respectively. TEAD-IN-11 (compound 38) functions as a selective covalent inhibitor of these TEAD isoforms. TEAD-IN-11 (compound 38) is applicable to investigations involving Hippo pathway signaling, TEAD-mediated transcriptional regulation, and cancer-associated proliferative signaling mechanisms.

Cas No. 3032196-88-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$54	4-6 weeks	4-6 weeks
5 mg	$127	4-6 weeks	4-6 weeks
10 mg	$198	4-6 weeks	4-6 weeks
25 mg	$413	4-6 weeks	4-6 weeks
50 mg	$662	4-6 weeks	4-6 weeks
100 mg	$926	4-6 weeks	4-6 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	TEAD-IN-11 (compound 38) exhibits potent inhibitory activity against TEAD1, TEAD2, and TEAD3, with IC50 values of 8.7, 3.4, and 5.6 nM, respectively. TEAD-IN-11 (compound 38) functions as a selective covalent inhibitor of these TEAD isoforms. TEAD-IN-11 (compound 38) is applicable to investigations involving Hippo pathway signaling, TEAD-mediated transcriptional regulation, and cancer-associated proliferative signaling mechanisms.
Targets & IC50	TEAD1:8.7 nM, TEAD2:3.4 nM, TEAD3:5.6 nM
In vitro	TEAD-IN-11 exhibits a strong inhibitory effect on MCF-7 reporter gene assays (IC 50 ≤10 nM)[1]. TEAD-IN-11 demonstrates excellent selectivity for TEAD1 and TEAD2, achieving 93% and 95% inhibition respectively in HEK293T cells[1].
Synonyms	TEAD IN 11

Chemical Properties

Molecular Weight	293.28
Formula	C₁₆H₁₄F₃NO
Cas No.	3032196-88-3
Smiles	O=C(C=C)N1CCC(C#CC2=CC=C(C=C2)C(F)(F)F)C1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.66 mg/mL (9.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4097 mL	17.0486 mL	34.0971 mL	170.4855 mL
5 mM	0.6819 mL	3.4097 mL	6.8194 mL	34.0971 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: TEAD-IN-11 chemical structure | TEAD-IN-11 in vitro | TEAD-IN-11 formula | TEAD-IN-11 molecular weight