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PRMT6-IN-3

Name: PRMT6-IN-3
Brand: TargetMol
SKU: T73185
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73185Cas No. 2890765-10-1

PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.

PRMT6-IN-3

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Purity: 98.12%

Catalog No. T73185Cas No. 2890765-10-1

PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$113	-	In Stock
10 mg	$172	-	In Stock
25 mg	$297	-	In Stock
50 mg	$455	-	In Stock
100 mg	$637	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.12%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PRMT6-IN-3 is a selective PRMT6 inhibitor with an IC50 value of 192 nM.PRMT6-IN-3 has anticancer activity and induces apoptosis in cancer cells.
Targets&IC50	PRMT6:192 nM
In vitro	PRMT6-IN-3 (compound 25) (0-40 μM; 72 h) significantly induces apoptosis of cancer cells in a dose-dependent manner. Among them, a concentration of 40 μM could induce apoptosis in 43.44% and 35.08% of HCC827 and MDA-MB-435 cells, respectively.[1] PRMT6-IN-3 (80 μM; 3-7 days) has anti-proliferative activity against HCC827 and MDA-MB-435 cells.[1]

Chemical Properties

Molecular Weight	374.5
Formula	C₁₉H₂₆N₄O₂S
Cas No.	2890765-10-1
Smiles	C(N(CCNC)C)C1=CC(=CN=C1)C2=CC=C(NS(=O)(=O)C3CC3)C=C2

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (146.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6702 mL	13.3511 mL	26.7023 mL	133.5113 mL
5 mM	0.5340 mL	2.6702 mL	5.3405 mL	26.7023 mL
10 mM	0.2670 mL	1.3351 mL	2.6702 mL	13.3511 mL
20 mM	0.1335 mL	0.6676 mL	1.3351 mL	6.6756 mL
50 mM	0.0534 mL	0.2670 mL	0.5340 mL	2.6702 mL
100 mM	0.0267 mL	0.1335 mL	0.2670 mL	1.3351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc