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STAT3-IN-B9 (Synonyms: STAT3 IN B9, B9)
Catalog No. T28865 Copy Product Info
Purity: 98.19%
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STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
STAT3-IN-B9
Copy Product Info😃Good
Catalog No. T28865
Synonyms STAT3 IN B9, B9
STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
Cas No. 825611-06-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | In Stock | In Stock | |
| 2 mg | $165 | In Stock | In Stock | |
| 5 mg | $262 | In Stock | In Stock | |
| 10 mg | $388 | In Stock | In Stock | |
| 25 mg | $592 | In Stock | In Stock | |
| 50 mg | $828 | In Stock | In Stock | |
| 100 mg | $1,110 | In Stock | In Stock | |
| 200 mg | $1,480 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $283 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:98.19%
Appearance:Solid
Color:Yellow
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Product Introduction
STAT3-IN-B9 AI Summary
STAT3-IN-B9 exhibits binding affinity to various STAT3 mutants as well as wild-type STAT3. It demonstrates antiproliferative activity against several cancer cell lines harboring active STAT3, with varying IC50 values, indicating its potential as an inhibitor of cell growth. Additionally, the compound inhibits STAT3-dependent transcriptional activity in HeLa cells, suggesting a role in modulating gene expression mediated by STAT3. The selectivity ratio of the compound for a specific STAT3 mutant compared to wild-type STAT3 indicates its potential selectivity towards different STAT3 variants..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145. |
| Synonyms | STAT3 IN B9, B9 |
| Molecular Weight | 379.39 |
| Formula | C20H13NO5S |
| Cas No. | 825611-06-1 |
| Smiles | O=C1C=2C(C(=O)C=3C1=CC=CC3)=CC=C(S(NC4=CC=C(O)C=C4)(=O)=O)C2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.8 mg/mL (12.65 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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