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LC-MB12

Name: LC-MB12
Brand: TargetMol
SKU: T86805
Price: 137 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T86805Cas No. 2828438-38-4

Alias LCMB12

LC-MB12 is an orally active, selective and potent PROTAC FGFR2 complex that degrades FGFR2.LC-MB12 has antiproliferative and antitumor activity.LC-MB12 is used in the study of gastric cancer because of its inhibition of FGFR2 signaling.LC-MB12 has been shown to have antiproliferative and antitumor activity.LC-MB12 has been shown to have antiproliferative and antitumor activity.

LC-MB12

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Purity: 99.16%

Catalog No. T86805Alias LCMB12Cas No. 2828438-38-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$137	In Stock	In Stock
5 mg	$342	In Stock	In Stock
10 mg	$549	In Stock	In Stock
25 mg	$1,080	In Stock	In Stock
50 mg	$1,760	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$543	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.16%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	LC-MB12 is an orally active, selective and potent PROTAC FGFR2 complex that degrades FGFR2.LC-MB12 has antiproliferative and antitumor activity.LC-MB12 is used in the study of gastric cancer because of its inhibition of FGFR2 signaling.LC-MB12 has been shown to have antiproliferative and antitumor activity.LC-MB12 has been shown to have antiproliferative and antitumor activity.
Targets&IC50	KATO III cells:29.1 nM, NCI-H716 cells:3.2 nM, FGFR2:11.8 nM (DC50), SNU-16 cells:3.7 nM
In vitro	0.5-10000 nM LC-MB12, FGFR2 was degraded in KATO III in a time-dependent manner over 3-12 hours, DC50=11.8 nM. [1] 100 nM LC-MB12 treatment for 6 hours resulted in 77% degradation of FGFR2 in KATO III and 43% degradation in NCI-H1581. [1] 1-10000 nM LC-MB12 treatment for 72 h significantly inhibited the growth of KATO III, SNU-16, and NCI-H716 with IC50=29.1 nM (KATO III), IC50=3.7 nM (SNU-16), and IC50=3.2 nM (NCI-H716), respectively, and induced KATO III G0 /G1 phase block. [1]
In vivo	Oral administration of 20 mg/kg LC-MB12 was rapidly absorbed in mice (Cmax: 2.6 h) with oral bioavailability (F: 13%). Oral administration for 30 days was well tolerated and showed no significant hepatotoxicity or nephrotoxicity in mice. [1] 20 mg/kg/day LC-MB12 administered orally for 15 days inhibited tumor growth by 63.1% in the SNU-16 nude mouse xenograft model. [1]
Synonyms	LCMB12

Chemical Properties

Molecular Weight	899.78
Formula	C₄₃H₄₄Cl₂N₁₀O₈
Cas No.	2828438-38-4
Smiles	O=C(NC=1C(Cl)=C(OC)C=C(OC)C1Cl)N(C=2N=CN=C(C2)NC3=CC=C(C=C3)N4CCN(C(=O)C5CCN(C6=CC=C7C(=O)N(C(=O)C7=C6)C8C(=O)NC(=O)CC8)CC5)CC4)C

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 120 mg/mL(133.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1114 mL	5.5569 mL	11.1138 mL	55.5691 mL
5 mM	0.2223 mL	1.1114 mL	2.2228 mL	11.1138 mL
10 mM	0.1111 mL	0.5557 mL	1.1114 mL	5.5569 mL
20 mM	0.0556 mL	0.2778 mL	0.5557 mL	2.7785 mL
50 mM	0.0222 mL	0.1111 mL	0.2223 mL	1.1114 mL
100 mM	0.0111 mL	0.0556 mL	0.1111 mL	0.5557 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc