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PSI-7409

Name: PSI-7409
Brand: TargetMol
SKU: T12572
Rating: 4.5 (1 reviews)

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Catalog No. T12572Cas No. 1015073-42-3

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

PSI-7409

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Catalog No. T12572Cas No. 1015073-42-3

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	Inquiry	3-6 months	3-6 months
50 mg	Inquiry	3-6 months	3-6 months
100 mg	Inquiry	3-6 months	3-6 months

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977).
In vitro	The active triphosphate, PSI-7409, inhibited recombinant NS5B polymerases from genotypes 1 to 4 with comparable 50% inhibitory concentrations.?PSI-7409 also lacked any significant activity against cellular DNA and RNA polymerases.?No cytotoxicity, mitochondrial toxicity, or bone marrow toxicity was associated with PSI-7851 at the highest concentration tested (100 microM)[1].

Chemical Properties

Molecular Weight	500.16
Formula	C₁₀H₁₆FN₂O₁₄P₃
Cas No.	1015073-42-3
Smiles	C[C@]1(F)[C@@](O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@H]1O)(N2C(=O)NC(=O)C=C2)[H]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (99.97 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9994 mL	9.9968 mL	19.9936 mL	99.9680 mL
5 mM	0.3999 mL	1.9994 mL	3.9987 mL	19.9936 mL
10 mM	0.1999 mL	0.9997 mL	1.9994 mL	9.9968 mL
20 mM	0.1000 mL	0.4998 mL	0.9997 mL	4.9984 mL
50 mM	0.0400 mL	0.1999 mL	0.3999 mL	1.9994 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc