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Thalidomide-O-C8-NH2 hydrochloride

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Catalog No. T40261Cas No. 2636798-38-2
Alias Thalidomide-O-C8-NH2 hydrochloride

Thalidomide-O-C8-NH2 hydrochloride is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide, as well as a linker employed in PROTAC technology.

Thalidomide-O-C8-NH2 hydrochloride

Thalidomide-O-C8-NH2 hydrochloride

😃Good
Catalog No. T40261Alias Thalidomide-O-C8-NH2 hydrochlorideCas No. 2636798-38-2
Thalidomide-O-C8-NH2 hydrochloride is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide, as well as a linker employed in PROTAC technology.
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25 mg$69635 days35 days
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Product Introduction

Bioactivity
Description
Thalidomide-O-C8-NH2 hydrochloride is a chemical compound consisting of a synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand derived from Thalidomide, as well as a linker employed in PROTAC technology.
In vitro
PROTACs feature two ligands linked together: one targets an E3 ubiquitin ligase, while the other binds to the target protein. They harness the intracellular ubiquitin-proteasome system to selectively degrade specific proteins [2].
SynonymsThalidomide-O-C8-NH2 hydrochloride
Chemical Properties
Molecular Weight437.92
FormulaC21H28ClN3O5
Cas No.2636798-38-2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Thalidomide-O-C-8-NH2 hydrochlorideThalidomideOC8NH2 hydrochlorideThalidomide-O-C8-NH2 HydrochlorideThalidomide O C8 NH2 hydrochloride
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