store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2
Pack Size | Availability | Price/USD | Quantity |
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2 mg | In stock | $ 176.00 |
Description | SH-42 is an inhibitor of 24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2 |
Targets&IC50 | DHCR24:42 nM (IC50) |
Molecular Weight | 402.575 |
Formula | C25H38O4 |
CAS No. | 2143952-36-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform: 10 mg/mL
You can also refer to dose conversion for different animals. More
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SH-42 2143952-36-5 SH 42 SH42 inhibitor inhibit