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UR778Br

Name: UR778Br
Brand: TargetMol
SKU: T88760
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: UR 778Br) Copy Product Info

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Synonyms: UR 778Br

Catalog No. T88760 Copy Product Info

Purity: 99.89%

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UR778Br targets the GTPase-activating protein-related domain (GRD domain) of the IQGAP1 protein. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML) cells by inducing G2/M phase cell-cycle arrest and promoting apoptosis. UR778Br suppresses colony formation in primary cells and AML cells without significant effects on normal bone marrow cells. UR778Br is therefore relevant for investigations involving IQGAP1-mediated signaling, hematologic malignancy biology, and cell-cycle regulatory mechanisms.

Cas No. 866127-80-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$32	-	In Stock
5 mg	$73	-	In Stock
10 mg	$123	-	In Stock
25 mg	$247	-	In Stock
50 mg	$396	-	In Stock
100 mg	$645	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:Orange

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	UR778Br targets the GTPase-activating protein-related domain (GRD domain) of the IQGAP1 protein. UR778Br inhibits the proliferation of human acute myeloid leukemia (AML) cells by inducing G2/M phase cell-cycle arrest and promoting apoptosis. UR778Br suppresses colony formation in primary cells and AML cells without significant effects on normal bone marrow cells. UR778Br is therefore relevant for investigations involving IQGAP1-mediated signaling, hematologic malignancy biology, and cell-cycle regulatory mechanisms.
In vitro	UR778Br (0-100 μM, 72 h) inhibits proliferation, induced apoptosis, resulted in G2/M arrest, and inhibits colony formation by leukemia cell-lines and primary-AML detected by fow cytometry[1].
Synonyms	UR 778Br

Chemical Properties

Molecular Weight	418.28
Formula	C₂₀H₂₀BrNO₄
Cas No.	866127-80-2
Smiles	O=C(C=1C=CC=CC1O)CC2(O)C(=O)N(C3=CC=C(Br)C=C32)CCCC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11.2 mg/mL (26.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3907 mL	11.9537 mL	23.9074 mL	119.5372 mL
5 mM	0.4781 mL	2.3907 mL	4.7815 mL	23.9074 mL
10 mM	0.2391 mL	1.1954 mL	2.3907 mL	11.9537 mL
20 mM	0.1195 mL	0.5977 mL	1.1954 mL	5.9769 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: UR778Br chemical structure | UR778Br in vitro | UR778Br formula | UR778Br molecular weight