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Bupivacaine

Name: Bupivacaine
Brand: TargetMol
SKU: T0030L
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0030LCas No. 38396-39-3

Alias Exparel, Bupivacaina, Anekain, AH-250, AH250, AH 250

Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.

Bupivacaine

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Purity: 99.83%

Catalog No. T0030LAlias Exparel, Bupivacaina, Anekain, AH-250, AH250, AH 250Cas No. 38396-39-3

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
In vitro	Bupivacaine inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, a key area in central sensitization[1]. It affects the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward more negative potentials. SCN5A channels are slightly sensitive to Bupivacaine in their inactivated state (IC50=2.18±0.16 μM)[2]. Additionally, Bupivacaine reversibly inhibits the SK2 channel in a dose-dependent manner with an IC50 of 16.5 µM[3].
Synonyms	Exparel, Bupivacaina, Anekain, AH-250, AH250, AH 250

Chemical Properties

Molecular Weight	288.43
Formula	C₁₈H₂₈N₂O
Cas No.	38396-39-3
Smiles	CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C
Relative Density.	1.032 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (86.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4670 mL	17.3352 mL	34.6705 mL	173.3523 mL
5 mM	0.6934 mL	3.4670 mL	6.9341 mL	34.6705 mL
10 mM	0.3467 mL	1.7335 mL	3.4670 mL	17.3352 mL
20 mM	0.1734 mL	0.8668 mL	1.7335 mL	8.6676 mL
50 mM	0.0693 mL	0.3467 mL	0.6934 mL	3.4670 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc