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IK-930

Name: IK-930
Brand: TargetMol
SKU: T77580
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T77580Cas No. 2563892-44-2

Alias compound I-32

IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.

IK-930

🥰Excellent

Purity: 98.86%

Catalog No. T77580Alias compound I-32Cas No. 2563892-44-2

IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.

Pack Size	Price	Availability
5 mg	$51	In Stock
10 mg	$84	In Stock
25 mg	$172	In Stock
50 mg	$278	In Stock
100 mg	$452	In Stock

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Batch Information

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Purity:98.86%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
Targets&IC50	TEAD:<0.1 µM(EC50)
In vitro	IK-930 (0-1 μM) is a potent and selective TEAD inhibitor.[2]
In vivo	IK-930 (compound I-32) (10 mg/kg; p.o.) demonstrates favorable pharmacokinetic parameters in BALB/c mice, with a Cmax of 1088 ng/mL and an AUC 0-last of 4581 ng·h/mL.[1]
Synonyms	compound I-32

Chemical Properties

Molecular Weight	424.44
Formula	C₁₉H₁₉F₃N₄O₂S
Cas No.	2563892-44-2
Smiles	N(CC1=CC=C(C(F)(F)F)C=C1)C2=C(C=C(S(NC)(=O)=O)C=C2)C=3N=CN(C)C3
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (212.0 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3560 mL	11.7802 mL	23.5605 mL	117.8023 mL
5 mM	0.4712 mL	2.3560 mL	4.7121 mL	23.5605 mL
10 mM	0.2356 mL	1.1780 mL	2.3560 mL	11.7802 mL
20 mM	0.1178 mL	0.5890 mL	1.1780 mL	5.8901 mL
50 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3560 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	1.1780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc