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ZIM

Catalog No. T72024 CAS 301298-87-3

ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.

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ZIM, CAS 301298-87-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 296.00
100 mg	In stock	$ 476.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.13%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

ZIM (i.p., 12, 24, and 48 mg/kg) effectively reduces the chromosomal micronucleus frequency at all doses in adult male Swiss mice, with a chemical preventive effect observed at 24 and 72 hours, and the range of percentage decrease in damage is between 38.36% and 83.26%.[1]
ZIM (i.p., 12, 24, and 48 mg/kg) lowers the frequency of liver cell and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX. At concentrations of 12, 24, and 48 mg/kg, the percentage decrease in liver damage in the CIS group is 79.27%, 75.20%, and 52.84%, respectively, while in the DOX group, it is 62.06%, 59.44%, and 77.80%. The percentage decrease in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.[1]

Molecular Weight	349.38
Formula	C20H19N3O3
CAS No.	301298-87-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (128.8 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Oliveira RJ, et al. ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics. Chem Res Toxicol. 2023;36(1):66-82. 2. Shikata M, et al. Characterization of Arabidopsis ZIM, a member of a novel plant-specific GATA factor gene family. J Exp Bot. 2004;55(397):631-639. 3. Chung HS, et al. A critical role for the TIFY motif in repression of jasmonate signaling by a stabilized splice variant of the JASMONATE ZIM-domain protein JAZ10 in Arabidopsis. Plant Cell. 2009;21(1):131-145.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library DNA Damage & Repair Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ZIM 301298-87-3 inhibitor inhibit

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