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ZIM

🥰Excellent
Catalog No. T72024Cas No. 301298-87-3

ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.

ZIM

ZIM

🥰Excellent
Purity: 99.85%
Catalog No. T72024Cas No. 301298-87-3
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$37In StockIn Stock
25 mg$75In StockIn Stock
50 mg$125In StockIn Stock
100 mg$200In StockIn Stock
1 mL x 10 mM (in DMSO)$34In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.85%
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Product Introduction

Bioactivity
Description
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation. Its properties highlight its potential as a chemotherapeutic agent in cancer research.
In vivo
ZIM (i.p., 12, 24, and 48 mg/kg) significantly reduces chromosomal micronucleus frequency at all doses in adult male Swiss mice, exhibiting a chemopreventive effect within 24 to 72 hours, and achieving damage reduction between 38.36% and 83.26%.[1] Additionally, ZIM at these concentrations lowers liver and kidney cell death induced by cisplatin-CIS and doxorubicin-DOX, with a decrease in liver damage in the CIS group of 79.27%, 75.20%, and 52.84%, respectively, and 62.06%, 59.44%, and 77.80% in the DOX group. The reduction in kidney damage in the CIS group is 45.29%, 36.09%, and 41.61%, respectively, and in the DOX group, it is 28.00%, 21.41%, and 30.82%.[1]
Chemical Properties
Molecular Weight349.38
FormulaC20H19N3O3
Cas No.301298-87-3
SmilesCN1N(C(=O)C(N2C(=O)C3C4CC(C=C4)C3C2=O)=C1C)C1=CC=CC=C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mg/mL (28.62 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8622 mL14.3111 mL28.6221 mL143.1107 mL
5 mM0.5724 mL2.8622 mL5.7244 mL28.6221 mL
10 mM0.2862 mL1.4311 mL2.8622 mL14.3111 mL
20 mM0.1431 mL0.7156 mL1.4311 mL7.1555 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

ZIMRNASynthesisRNA SynthesisDNASynthesisDNA/RNA SynthesisDNA Synthesis
Related Tags: buy ZIM | purchase ZIM | ZIM cost | order ZIM | ZIM chemical structure | ZIM in vivo | ZIM formula | ZIM molecular weight
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