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ALW-II-49-7

Name: ALW-II-49-7
Brand: TargetMol
SKU: T67736
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T67736Cas No. 1135219-23-6

ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase, with an EC50 value of 40 nM in cell.

ALW-II-49-7

🥰Excellent

Purity: 99.72%

Catalog No. T67736Cas No. 1135219-23-6

ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase, with an EC50 value of 40 nM in cell.

Pack Size	Price	Availability
1 mg	$65	In Stock
5 mg	$169	In Stock
10 mg	$255	In Stock
25 mg	$463	In Stock
50 mg	$682	In Stock
100 mg	$969	In Stock
500 mg	$1,950	In Stock
1 mL x 10 mM (in DMSO)	$186	In Stock

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Batch Information

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Purity:99.72%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	ALW-II-49-7 is a selective and potent inhibitor of EphB2 kinase, with an EC50 value of 40 nM in cell.
In vitro	ALW-II-49-7 (0.01-10 μ M; 1 h) inhibits the activity of EphB2 kinase in U87 glioblastoma cells at a concentration of 2 μ g/mL[1].

Chemical Properties

Molecular Weight	414.38
Formula	C₂₁H₁₇F₃N₄O₂
Cas No.	1135219-23-6
Smiles	N(C1=CC(C(NC2=CC(C(F)(F)F)=CC=C2)=O)=CC=C1C)C=3C=C(C(N)=O)C=NC3
Relative Density.	1.399 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (60.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4132 mL	12.0662 mL	24.1324 mL	120.6622 mL
5 mM	0.4826 mL	2.4132 mL	4.8265 mL	24.1324 mL
10 mM	0.2413 mL	1.2066 mL	2.4132 mL	12.0662 mL
20 mM	0.1207 mL	0.6033 mL	1.2066 mL	6.0331 mL
50 mM	0.0483 mL	0.2413 mL	0.4826 mL	2.4132 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc