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Imiquimod maleate

Name: Imiquimod maleate
Brand: TargetMol
SKU: T22862
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22862Cas No. 896106-16-4

Alias R837 maleate, R 837 maleate

Imiquimod maleate (R 837 maleate) is a toll-like receptor 7 (TLR7) agonist and immune response modifier with antiviral and antitumor activities. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and can induce psoriasis-like skin lesions in mice, commonly used to establish psoriasis models.

Imiquimod maleate

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Purity: 99.98%

Catalog No. T22862Alias R837 maleate, R 837 maleateCas No. 896106-16-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$29	-	In Stock
50 mg	$39	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Imiquimod maleate (R 837 maleate) is a toll-like receptor 7 (TLR7) agonist and immune response modifier with antiviral and antitumor activities. It is used in the study of external genital warts, perianal warts, cancer, and COVID-19, and can induce psoriasis-like skin lesions in mice, commonly used to establish psoriasis models.
In vivo	In animal models, Imiquimod maleate stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α, and inducing proliferation and differentiation of B lymphocytes. [1]
Synonyms	R837 maleate, R 837 maleate

Chemical Properties

Molecular Weight	356.38
Formula	C₁₈H₂₀N₄O₄
Cas No.	896106-16-4
Smiles	C(=C\C(O)=O)\C(O)=O.C(C(C)C)N1C=2C=3C(N=C(N)C2N=C1)=CC=CC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (2.81 mM), Sonication is recommended.

DMSO: 20 mg/mL (56.12 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8060 mL	14.0300 mL	28.0599 mL	140.2997 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5612 mL	2.8060 mL	5.6120 mL	28.0599 mL
10 mM	0.2806 mL	1.4030 mL	2.8060 mL	14.0300 mL
20 mM	0.1403 mL	0.7015 mL	1.4030 mL	7.0150 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	2.8060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc