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GCN2-IN-7

Name: GCN2-IN-7
Brand: TargetMol
SKU: T63699
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63699Cas No. 2396465-33-9

GCN2-IN-7 is an orally active, potent and selective inhibitor of the environmental sensing protein GCN2 with anti-tumor activity and can be used to study melanoma.

GCN2-IN-7

🥰Excellent

Purity: 99.12%

Catalog No. T63699Cas No. 2396465-33-9

GCN2-IN-7 is an orally active, potent and selective inhibitor of the environmental sensing protein GCN2 with anti-tumor activity and can be used to study melanoma.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$313	In Stock	In Stock
5 mg	$787	In Stock	In Stock
10 mg	$1,320	In Stock	In Stock
25 mg	$2,130	In Stock	In Stock
50 mg	$2,780	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.12%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	GCN2-IN-7 is an orally active, potent and selective inhibitor of the environmental sensing protein GCN2 with anti-tumor activity and can be used to study melanoma.
In vitro	600 nM GCN2-IN-7 alleviates myeloid-derived suppressive cells (MDSC)-related T cell suppression and restores T cell proliferation. [1]
In vivo	Twice daily oral gavage of 15 mg/kg GCN2-IN-7 for 17 days showed potent target binding activity at reasonable doses. Twice daily oral gavage of 50 mg/kg GCN2-IN-7 for 17 days inhibited tumor growth in an LL2 homozygous mouse tumor model. [1]

Chemical Properties

Molecular Weight	527.44
Formula	C₂₂H₂₃BrN₈OS
Cas No.	2396465-33-9
Smiles	BrC=1C=2C(N(N1)C3=CC=C(C=C3)C4=NN=C(C)S4)=NC(N[C@H]5C[C@@](C(NC)=O)(C)CC5)=NC2
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL(75.84 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8960 mL	9.4798 mL	18.9595 mL	94.7975 mL
5 mM	0.3792 mL	1.8960 mL	3.7919 mL	18.9595 mL
10 mM	0.1896 mL	0.9480 mL	1.8960 mL	9.4798 mL
20 mM	0.0948 mL	0.4740 mL	0.9480 mL	4.7399 mL
50 mM	0.0379 mL	0.1896 mL	0.3792 mL	1.8960 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc