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IV-361
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Catalog No. T39456Cas No. 2055741-39-2
IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).
IV-361
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Catalog No. T39456Cas No. 2055741-39-2
IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $871 | Inquiry | Inquiry | |
| 10 mg | $1,360 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1). |
| Targets&IC50 | CDK2:≥1000 nM (Ki), CDK7:≤50 nM (Ki) |
| In vitro | IV-361 demonstrates minimal inhibitory effects on CDK2 (K i ≥1000 nM) and PLK1 (K i ≥5000 nM), highlighting its specificity[1]. Moreover, it exhibits potent inhibition of IL-2 and IL-17 production (all IC 50 ≤100 nM) in peripheral blood mononuclear cells (PBMC), alongside significant growth inhibitory activity against HCT-116 cells (GI 50 ≤100 nM)[1]. |
| In vivo | IV-361, administered orally at a dosage of 25 mg/kg/day, demonstrates a suppression rate of 46% or greater in tumor volume in female BALB/c nude mice implanted with HCT-116[1]. |
| Molecular Weight | 457.625 |
| Formula | C23H32FN5O2Si |
| Cas No. | 2055741-39-2 |
| Smiles | Cc1ccc(F)cc1NC(=O)N1Cc2c(NC(=O)C3(CCC3)[Si](C)(C)C)n[nH]c2C1(C)C |
| Relative Density. | 1.24 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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