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NG-497

🥰Excellent
Catalog No. T73499Cas No. 2598242-66-9
Alias NG497

NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.

NG-497

NG-497

🥰Excellent
Purity: 99.56%
Catalog No. T73499Alias NG497Cas No. 2598242-66-9
NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.
Pack SizePriceAvailabilityQuantity
5 mg$59In Stock
10 mg$97In Stock
25 mg$197In Stock
50 mg$322In Stock
100 mg$538In Stock
1 mL x 10 mM (in DMSO)$66In Stock
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Purity:99.56%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.
In vitro
NG-497 selectively inactivates human and non-human primate ATGL, but not structurally and functionally related lipid hydrolases, and eliminates human adipocytes in a dose-dependent and reversible manner. Lipolysis.[1]
NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.[1]
SynonymsNG497
Chemical Properties
Molecular Weight315.36
FormulaC18H21NO4
Cas No.2598242-66-9
SmilesC(OC(C)C)(=O)C1=NC(=CC(OC)=C1)C2=CC=C(OCC)C=C2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (158.55 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1710 mL15.8549 mL31.7098 mL158.5490 mL
5 mM0.6342 mL3.1710 mL6.3420 mL31.7098 mL
10 mM0.3171 mL1.5855 mL3.1710 mL15.8549 mL
20 mM0.1585 mL0.7927 mL1.5855 mL7.9274 mL
50 mM0.0634 mL0.3171 mL0.6342 mL3.1710 mL
100 mM0.0317 mL0.1585 mL0.3171 mL1.5855 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

NG-497NG 497ATGL
Related Tags: buy NG-497 | purchase NG-497 | NG-497 cost | order NG-497 | NG-497 chemical structure | NG-497 in vitro | NG-497 formula | NG-497 molecular weight
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