Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 59.00 | |
10 mg | In stock | $ 97.00 | |
25 mg | In stock | $ 197.00 | |
50 mg | In stock | $ 322.00 | |
100 mg | In stock | $ 538.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 66.00 |
Description | NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adjacent to the active site.NG-497 abrogates lipolysis in human adipocytes in a dose-dependent and reversible manner.NG-497 has been shown to be useful in cancer research. can be used in cancer research. |
In vitro |
NG-497 selectively inactivates human and non-human primate ATGL, but not structurally and functionally related lipid hydrolases, and eliminates human adipocytes in a dose-dependent and reversible manner. Lipolysis.[1] NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.[1] |
Synonyms | NG497 |
Molecular Weight | 315.36 |
Formula | C18H21NO4 |
CAS No. | 2598242-66-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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NG-497 2598242-66-9 Metabolism Lipase NG497 NG 497 inhibitor inhibit