Shopping Cart

Your shopping cart is currently empty

PSMA-11

Name: PSMA-11
Brand: TargetMol
SKU: T28466
Price: 147 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T28466Cas No. 1366302-52-4

Alias Psma-hbed-CC, PSMA11, HBED-CC-PSMA

PSMA-11 (HBED-CC-PSMA) detects prostate cancer recurrence and metastasis by binding to the extracellular structural domain of prostate-specific membrane antigen (PSMA).PSMA-11 is often used as a tracer of PSMA-expressing tumours in positron emission tomography (PET) scanning by intravenous injection of gallium Ga 68-labelled PSMA-11, Glu-urea-Lys(Ahx) molecule targeted and bound PSMA-expressing tumour cells. After internalisation, PSMA-expressing tumour cells could be detected on PET imaging.

PSMA-11

Copy Product Info

😃Good

Purity: 99.09%

Catalog No. T28466Alias Psma-hbed-CC, PSMA11, HBED-CC-PSMACas No. 1366302-52-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$147	In Stock	In Stock
5 mg	$372	In Stock	In Stock
10 mg	$519	In Stock	In Stock
25 mg	$929	In Stock	In Stock
50 mg	$1,230	-	In Stock
100 mg	$1,670	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$542	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.09%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

PSMA-11 AI Summary

PSMA-11 exhibits potent bioactivity as an inhibitor for various targets with high specificity and selectivity. It shows strong inhibitory action against antiTEV-tagged GCP2 extracellular portion with a Ki value of 0.018 nM, and demonstrates inhibitory activity against antiTEV-tagged GCP3 extracellular portion with a Ki of 13.0 nM, resulting in a high selectivity ratio of 720.0 favoring GCP2. Additionally, PSMA-11 binds to PSMA in human LNCaP cells with a Ki of 12.0 nM and displays 10.63% cell surface binding and 9.47% specific internalization per 10^6 cells. Its HPLC retention time is 1.69 minutes, and it has a logD of -1.71 at pH 7.4. In xenografted mice, the compound shows a tumor to muscle uptake ratio of 4.9 as determined by microPET imaging..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PSMA-11 (HBED-CC-PSMA) detects prostate cancer recurrence and metastasis by binding to the extracellular structural domain of prostate-specific membrane antigen (PSMA).PSMA-11 is often used as a tracer of PSMA-expressing tumours in positron emission tomography (PET) scanning by intravenous injection of gallium Ga 68-labelled PSMA-11, Glu-urea-Lys(Ahx) molecule targeted and bound PSMA-expressing tumour cells. After internalisation, PSMA-expressing tumour cells could be detected on PET imaging.
Targets&IC50	GCP III:0.013 µM(Ki), GCP II:0.012 µM(Ki)
Synonyms	Psma-hbed-CC, PSMA11, HBED-CC-PSMA

Chemical Properties

Molecular Weight	946.99
Formula	C₄₄H₆₂N₆O₁₇
Cas No.	1366302-52-4
Smiles	OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)CCc1ccc(O)c(CN(CCN(CC(O)=O)Cc2cc(CCC(O)=O)ccc2O)CC(O)=O)c1)C(O)=O)C(O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (95.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (3.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0560 mL	5.2799 mL	10.5598 mL	52.7989 mL
5 mM	0.2112 mL	1.0560 mL	2.1120 mL	10.5598 mL
10 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2799 mL
20 mM	0.0528 mL	0.2640 mL	0.5280 mL	2.6399 mL
50 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0560 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc