Shopping Cart
Remove All
Your shopping cart is currently empty
NX-5948
Copy Product Info
😃Good
Catalog No. T75124Cas No. 2649400-34-8
Alias NX5948, BTK-IN-24
NX-5948 (BTK-IN-24) is an orally bioavailable and blood-brain barrier-penetrable PROTAC BTK degrader with anti-inflammatory and antitumor activities. It induces BTK protein degradation via the cereblon E3 ligase complex, inhibiting B cell activation.
NX-5948
Copy Product Info😃Good
Purity: 98.29%
Catalog No. T75124Alias NX5948, BTK-IN-24Cas No. 2649400-34-8
NX-5948 (BTK-IN-24) is an orally bioavailable and blood-brain barrier-penetrable PROTAC BTK degrader with anti-inflammatory and antitumor activities. It induces BTK protein degradation via the cereblon E3 ligase complex, inhibiting B cell activation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $77 | - | In Stock | |
| 5 mg | $156 | - | In Stock | |
| 10 mg | $235 | - | In Stock | |
| 25 mg | $376 | - | In Stock | |
| 50 mg | $567 | - | In Stock | |
| 100 mg | $787 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:98.29%
Appearance:Solid
Color:Yellow
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NX-5948 (BTK-IN-24) is an orally bioavailable and blood-brain barrier-penetrable PROTAC BTK degrader with anti-inflammatory and antitumor activities. It induces BTK protein degradation via the cereblon E3 ligase complex, inhibiting B cell activation. |
| Targets&IC50 | BTK in primary B cells (human):0.34 nM (DC50) |
| In vitro | NX-5948 (0.0001-1000 nM; 4 hrs) is a potent degrader of BTK in primary human B cells (DC50=0.34 nM) and inhibits BCR signaling. In Ramos cells, NX-5948 (10 nM; 0.25, 0.5, 1, 2, 4, 6, 18, 24 hr) rapidly catalyzes BTK degradation within 1 hr and completes the degradation process within 2 hr. [1] NX-5948 induces BTK degradation in lymphoma cell lines and PBMC (DC50< 1 nM). [3] |
| In vivo | In a mouse model of collagen-induced arthritis (CIA), NX-5948 (10, 30 mg/kg; oral gavage; daily; days 18-36) demonstrated good efficacy and tolerability, inhibiting antibody titers and cytokine IL-6 levels. [1] NX-5948 (3, 10, 30 mg/kg; oral gavage) caused dose- and time-dependent decreases in circulating BTK levels in mice and non-human primate and cynomolgus monkeys. [1] |
| Synonyms | NX5948, BTK-IN-24 |
| Molecular Weight | 806.96 |
| Formula | C42H54N12O5 |
| Cas No. | 2649400-34-8 |
| Smiles | N(C=1N=C(C=NC1C(N)=O)N2C[C@@H](CCC2)N3C(=O)N(C)CC3)C4=CC=C(C=C4)C5CCN(CC6CCN(CC6)C=7C=CC(C(N[C@@H]8C(=O)NC(=O)CC8)=O)=NC7)CC5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (49.57 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (4.09 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy NX-5948 | purchase NX-5948 | NX-5948 cost | order NX-5948 | NX-5948 chemical structure | NX-5948 in vivo | NX-5948 in vitro | NX-5948 formula | NX-5948 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.