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Brazilein
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Catalog No. T75502Cas No. 600-76-0
Brazilein, a natural anti-inflammatory and antioxidant from Caesalpinia sappan L., inhibits adipocyte differentiation by inhibiting PPAR γ induction, inhibits the growth of skin cancer cells through increasing caspase-3 activity, and also possesses insecticidal activity.
Brazilein
Copy Product Info😃Good
Catalog No. T75502Cas No. 600-76-0
Brazilein, a natural anti-inflammatory and antioxidant from Caesalpinia sappan L., inhibits adipocyte differentiation by inhibiting PPAR γ induction, inhibits the growth of skin cancer cells through increasing caspase-3 activity, and also possesses insecticidal activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $229 | - | In Stock | |
| 5 mg | $1,060 | 35 days | 35 days | |
| 10 mg | $1,970 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Brazilein, a natural anti-inflammatory and antioxidant from Caesalpinia sappan L., inhibits adipocyte differentiation by inhibiting PPAR γ induction, inhibits the growth of skin cancer cells through increasing caspase-3 activity, and also possesses insecticidal activity. |
| In vitro | Brazilein at 1, 5, and 10 μg/mL induces apoptosis in spleen lymphocytes after 72 hours in the presence of mitogens. [1] Brazilein at 1, 5, and 10 μg/mL inhibits the proliferation of T and B lymphocytes induced by Con A and LPS in vitro after 72 hours, as measured by MTT assay. [1] |
| In vivo | Mice treated with Brazilein (50 mg/kg, i.p.) once daily for 7 days experienced dose-dependent atrophy and weight loss of the thymus and spleen, with thymus/spleen-to-body-weight ratios significantly reduced compared to the control group. [1] In ICR mice, i.p. administration of Brazilein at 25 or 50 mg/kg for 7 consecutive days, followed by SRBC immunization on day 8, significantly decreased splenic PFC numbers measured on day 12, indicating suppression of the humoral immune response. [1] |
| Molecular Weight | 284.26 |
| Formula | C16H12O5 |
| Cas No. | 600-76-0 |
| Smiles | O=C1C=C2C(C=C1O)=C3C=4C=CC(O)=CC4OCC3(O)C2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMF: 8 mg/mL (28.14 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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