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Pilloin
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Catalog No. TN2073Cas No. 32174-62-2
Pilloin is a synthetic small molecule employed in chemical biology research for its activity as a selective ATP-competitive kinase modulator. Pilloin influences downstream signaling events such as cellular proliferation, differentiation, and apoptosis, making Pilloin a valuable tool for dissecting oncogenic signaling networks, inflammatory pathways, and metabolic regulation in vitro, and it supports proof-of-concept studies in preclinical disease models.
Pilloin
😃Good
Purity: 99.04%
Catalog No. TN2073Cas No. 32174-62-2
Pilloin is a synthetic small molecule employed in chemical biology research for its activity as a selective ATP-competitive kinase modulator. Pilloin influences downstream signaling events such as cellular proliferation, differentiation, and apoptosis, making Pilloin a valuable tool for dissecting oncogenic signaling networks, inflammatory pathways, and metabolic regulation in vitro, and it supports proof-of-concept studies in preclinical disease models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $48 | - | In Stock | |
| 5 mg | $106 | - | In Stock | |
| 10 mg | $156 | - | In Stock | |
| 25 mg | $262 | - | In Stock | |
| 50 mg | $389 | - | In Stock | |
| 100 mg | $572 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.04%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pilloin is a synthetic small molecule employed in chemical biology research for its activity as a selective ATP-competitive kinase modulator. Pilloin influences downstream signaling events such as cellular proliferation, differentiation, and apoptosis, making Pilloin a valuable tool for dissecting oncogenic signaling networks, inflammatory pathways, and metabolic regulation in vitro, and it supports proof-of-concept studies in preclinical disease models. |
| In vitro | Pilloin (3–30 μM, 1–24 hours) significantly inhibited the transcriptional activity of NF-κB and the phosphorylation of its upstream regulatory protein IκB in bacterial LPS-induced RAW 264.7 cells, while only causing slight cytotoxicity at 30 μM, with a cell survival rate of 85% [3]. |
| In vivo | Pilloin (10 mg/kg, i.p.) significantly reduced the expression levels of pro-inflammatory cytokines TNF-α and IL-6 in the serum of LPS-induced septic C57BL/6 male mice. At the same time, Pilloin also markedly inhibited IL-6 expression in multiple organs (liver, lung, spleen, and kidney). |
| Molecular Weight | 314.29 |
| Formula | C17H14O6 |
| Cas No. | 32174-62-2 |
| Smiles | O=C1C=C(OC=2C=C(OC)C=C(O)C12)C=3C=CC(OC)=C(O)C3 |
| Relative Density. | 1.402 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24 mg/mL (76.36 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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