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TH5427 hydrochloride

Catalog No. T39785 CAS 2253744-57-7

TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.

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TH5427 hydrochloride, CAS 2253744-57-7

Pack Size	Availability	Price/USD	Quantity
10 mg	35 days	$ 478.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	TH5427 hydrochloride is a potent and selective inhibitor of NUDT5 with an IC50 of 29 nM. It demonstrates a remarkable 690-fold selectivity towards NUDT5 compared to MTH1. Moreover, TH5427 hydrochloride effectively inhibits progestin-dependent, PAR-derived nuclear ATP synthesis in breast cancer cells, thereby impeding chromatin remodeling, gene regulation, and ultimately suppressing proliferation.
In vitro	TH5427 hydrochloride effectively suppresses progestin-induced nuclear ATP synthesis in breast cancer cells and markedly inhibits both EGFR and MMTV-luc expression post-progestin stimulation. Furthermore, TH5427 hydrochloride nullifies the proliferative response dependent on progestin in T47D WT cells[1].

Molecular Weight	527.79
Formula	C20H21Cl3N8O3
CAS No.	2253744-57-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells [published correction appears in Nat Commun. 2019 Nov 1;10(1):5050]. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH5427 hydrochloride 2253744-57-7 TH-5427 Hydrochloride TH 5427 Hydrochloride TH5427 Hydrochloride TH-5427 hydrochloride inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.