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Vorozole

Name: Vorozole
Brand: TargetMol
SKU: T26322
Price: 191 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T26322Cas No. 129731-10-8

Alias R83842, R-83839, R83839, R 83839, (+)-Vorozole

Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer.

Vorozole

🥰Excellent

Purity: 99.87%

Catalog No. T26322Alias R83842, R-83839, R83839, R 83839, (+)-VorozoleCas No. 129731-10-8

Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer.

Pack Size	Price	Availability
1 mg	$191	In Stock
5 mg	$480	In Stock
10 mg	$687	In Stock
25 mg	$1,080	In Stock
50 mg	$1,480	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.87%

ee:98.88%

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Product Introduction

Bioactivity

Description	Vorozole (R83842) is an orally active, potent, and selective nonsteroidal aromatase inhibitor.Vorozole exhibits antitumor activity in vivo and may be used in the study of breast cancer.
In vitro	Vorozole inhibits aromatase activity in FSH-stimulated rat granulosa cells with an IC 50 s of 1.4 nM.[3]
In vivo	Vorozole (0.8-1.25 mg/kg; Gavage; daily for 77 days; Female Sprague-Dawley rats) demonstrates antitumor effects and increases serum levels of insulin-like growth factor (IGF)-1 and testosterone.[3] Additionally, Vorozole (0.8-1.25 mg/kg; p.o.; 5 days; Female Sprague-Dawley rats) reduces uterine weight in a dose-dependent manner and effectively suppresses tumor aromatase in ovariectomized nude mice.[3]
Synonyms	R83842, R-83839, R83839, R 83839, (+)-Vorozole

Chemical Properties

Molecular Weight	324.77
Formula	C₁₆H₁₃ClN₆
Cas No.	129731-10-8
Smiles	[C@@H](C=1C=C2C(=CC1)N=NN2C)(C3=CC=C(Cl)C=C3)N4C=NC=N4
Relative Density.	1.44g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (153.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0791 mL	15.3955 mL	30.7910 mL	153.9551 mL
5 mM	0.6158 mL	3.0791 mL	6.1582 mL	30.7910 mL
10 mM	0.3079 mL	1.5396 mL	3.0791 mL	15.3955 mL
20 mM	0.1540 mL	0.7698 mL	1.5396 mL	7.6978 mL
50 mM	0.0616 mL	0.3079 mL	0.6158 mL	3.0791 mL
100 mM	0.0308 mL	0.1540 mL	0.3079 mL	1.5396 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc