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Stictic Acid

Name: Stictic Acid
Brand: TargetMol
SKU: T35673
Rating: 4.5 (1 reviews)

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Catalog No. T35673Cas No. 549-06-4

Alias Scopularic acid

Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.

Stictic Acid

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Purity: 97.07%

Catalog No. T35673Alias Scopularic acidCas No. 549-06-4

Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$215	Inquiry	Inquiry
1 mg	$318	Inquiry	Inquiry
5 mg	$733	Inquiry	Inquiry
10 mg	$995	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$751	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.07%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Stictic Acid AI Summary

Stictic Acid exhibits a wide range of bioactivities across various biological systems. It shows potent bioactivity against HIV-1 integrase, inhibiting both 3'-processing and strand transfer activities with strong IC50 values. The compound also demonstrates inhibitory effects against disintegration of HIV-1 integrase, albeit with a higher IC50 value. Additionally, it inhibits the uptake of sodium fluorescein in OATP1B1- and OATP1B3-transfected CHO cells, exhibits low cytotoxicity against human HL60, HeLa, and African green monkey Vero cells, and shows good chemical stability in methanol. In growth retardation studies, Stictic Acid affects the larval and pupal weight and duration of Spodoptera littoralis larvae. It also inhibits various enzymes and proteins, including Phosphoglycerate Kinase, Glutaminase, translin/trax in E. coli, and soluble guanylate cyclase (sGC) in human and bovine cells. The compound shows antibacterial activity against several strains like Klebsiella pneumoniae MDR, Staphylococcus aureus MRSA, Pseudomonas aeruginosa, and Escherichia coli, but weaker antifungal activity. Notably, it demonstrates a degree of inhibition against SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Further bioactivities include the inhibition of enzymes such as PHPT1, FabZ from Yersinia pestis and Francisella tularensis, and Salmonella typhimurium LsrK kinase. Stictic Acid also affects interactions in signaling pathways by inhibiting p115 DHPH22 domain interaction with RhoA F25N mutant, indicating its potential in modulating these pathways. In sum, Stictic Acid is a multi-target bioactive molecule with significant inhibition capabilities across diverse biological processes and pathogens..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.
Synonyms	Scopularic acid

Chemical Properties

Molecular Weight	386.31
Formula	C₁₉H₁₄O₉
Cas No.	549-06-4
Smiles	OC1C=2C3=C(C(C)=C(O)C2C(=O)O1)OC(=O)C=4C(O3)=C(C=O)C(OC)=CC4C
Relative Density.	1.591 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 11 mg/mL (28.47 mM), Sonication is recommended.

DMF: Soluble

Methanol: Soluble

Ethanol: Soluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5886 mL	12.9430 mL	25.8859 mL	129.4297 mL
5 mM	0.5177 mL	2.5886 mL	5.1772 mL	25.8859 mL
10 mM	0.2589 mL	1.2943 mL	2.5886 mL	12.9430 mL
20 mM	0.1294 mL	0.6471 mL	1.2943 mL	6.4715 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc