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Fisetin quarterhydrate

Catalog No. T78538

Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotective effects.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Fisetin quarterhydrate Chemical Structure

Fisetin quarterhydrate, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fisetin quarterhydrate, a natural flavonol present in numerous fruits and vegetables, exhibits benefits including antioxidant, anticancer, and neuroprotective effects.
In vitro	Fisetin quarterhydrate suppresses lipid accumulation and diminishes the expression of PPARγ in 3T3-L1 cells. It inhibits the early stages of preadipocyte differentiation and induces the expression of Sirt1, further promoting Sirt1-mediated deacetylation of PPARγ and FoxO1, enhancing the binding of Sirt1 to the PPARγ promoter and repressing PPARγ transcriptional activity, thereby inhibiting adipogenesis [1]. Fisetin quarterhydrate binds to tubulin, stabilizing microtubules more effectively than paclitaxel. In human prostate cancer cells, fisetin quarterhydrate treatment causes a pronounced upregulation of microtubule-associated proteins (MAP)-2 and -4, significantly inhibiting PCa cell proliferation, migration, and invasion. Nudc, a protein associated with microtubule motor dynein/dynactin complex regulating microtubule dynamics, is also downregulated with fisetin quarterhydrate treatment [2].
In vivo	Treatment with Fisetin quarterhydrate in mice exposed to UVB reduces proliferation and decreases the infiltration of inflammatory cells. This treatment also lowers levels of inflammatory mediators, such as COX-2, PGE2 and its receptors (EP1-EP4), and MPO activity. Moreover, Fisetin quarterhydrate reduces levels of pro-inflammatory cytokines, including TNFα, IL-1β, and IL-6, in UVB-exposed skin. Additionally, this treatment diminishes markers of cellular proliferation and DNA damage, as evidenced by the increased expression of the proteins p53 and p21 [3].

Molecular Weight	N/A
Formula	C15H10O6.1/4H2O

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Fisetin quarterhydrate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.