Shopping Cart

Your shopping cart is currently empty

Z-VEID-FMK

Name: Z-VEID-FMK
Brand: TargetMol
SKU: T23555
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T23555Cas No. 210344-96-0

Alias Z-VE(OMe)ID(OMe)-FMK

Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.

Z-VEID-FMK

😃Good

Catalog No. T23555Alias Z-VE(OMe)ID(OMe)-FMKCas No. 210344-96-0

Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$106	In Stock	In Stock
5 mg	$282	In Stock	In Stock
10 mg	$468	-	In Stock
25 mg	$747	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.
In vitro	Pretreatment of HepG2 by Z-VEID-FMK (50 μM, 1 h) reduced drug-induced caspase-6 activity in HepG2 cells by 53%, reduced apoptosis by 58%, and reduced DNA breakage by 44%. [1]
Synonyms	Z-VE(OMe)ID(OMe)-FMK

Chemical Properties

Molecular Weight	652.71
Formula	C₃₁H₄₅FN₄O₁₀
Cas No.	210344-96-0
Smiles	[C@@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@H](C)C)=O)CCC(OC)=O)=O)(C(N[C@@H](CC(OC)=O)C(CF)=O)=O)[C@H](CC)C
Relative Density.	no data available
Sequence	Cbz-DL-Val-DL-Glu(OMe)-DL-xiIle-DL-Asp(OMe)-CH2F
Sequence Short	VXXX

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (306.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.66 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5321 mL	7.6604 mL	15.3207 mL	76.6037 mL
5 mM	0.3064 mL	1.5321 mL	3.0641 mL	15.3207 mL
10 mM	0.1532 mL	0.7660 mL	1.5321 mL	7.6604 mL
20 mM	0.0766 mL	0.3830 mL	0.7660 mL	3.8302 mL
50 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5321 mL
100 mM	0.0153 mL	0.0766 mL	0.1532 mL	0.7660 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc