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Z-VEID-FMK

Name: Z-VEID-FMK
Brand: TargetMol
SKU: T23555
Price: 106 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23555Cas No. 210344-96-0

Alias Z-VE(OMe)ID(OMe)-FMK

Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.

Z-VEID-FMK

🥰Excellent

Catalog No. T23555Alias Z-VE(OMe)ID(OMe)-FMKCas No. 210344-96-0

Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.

Pack Size	Price	Availability
1 mg	$106	In Stock
5 mg	$282	In Stock
10 mg	$468	In Stock
25 mg	$747	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Z-VEID-FMK is a selective and cell-permeable caspase-6 peptide inhibitor that irreversibly covalently binds to the active site of the enzyme, thereby inhibiting apoptosis and DNA breakage.
In vitro	Pretreatment of HepG2 by Z-VEID-FMK (50 μM, 1 h) reduced drug-induced caspase-6 activity in HepG2 cells by 53%, reduced apoptosis by 58%, and reduced DNA breakage by 44%. [1]
Synonyms	Z-VE(OMe)ID(OMe)-FMK

Chemical Properties

Molecular Weight	652.71
Formula	C₃₁H₄₅FN₄O₁₀
Cas No.	210344-96-0
Smiles	[C@@H](NC([C@@H](NC([C@@H](NC(OCC1=CC=CC=C1)=O)[C@H](C)C)=O)CCC(OC)=O)=O)(C(N[C@@H](CC(OC)=O)C(CF)=O)=O)[C@H](CC)C
Relative Density.	no data available
Color	White
Appearance	Solid
Sequence	Cbz-DL-Val-DL-Glu(OMe)-DL-xiIle-DL-Asp(OMe)-CH2F
Sequence Short	VXXX

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (306.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5321 mL	7.6604 mL	15.3207 mL	76.6037 mL
5 mM	0.3064 mL	1.5321 mL	3.0641 mL	15.3207 mL
10 mM	0.1532 mL	0.7660 mL	1.5321 mL	7.6604 mL
20 mM	0.0766 mL	0.3830 mL	0.7660 mL	3.8302 mL
50 mM	0.0306 mL	0.1532 mL	0.3064 mL	1.5321 mL
100 mM	0.0153 mL	0.0766 mL	0.1532 mL	0.7660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc