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9-Hydroxyellipticine hydrochloride
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Catalog No. T10200Cas No. 52238-35-4
9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively.
9-Hydroxyellipticine hydrochloride
😃Good
Catalog No. T10200Cas No. 52238-35-4
9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $110 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | 9-Hydroxyellipticine hydrochloride is an inhibitor of Topo II and RyR, exhibiting antitumor, antioxidant, and catecholamine-releasing activities. It inhibits Hela S-3 and 293T cells with IC50s of 1.6 μM and 1.2 μM, respectively. |
| In vitro | 9-Hydroxyellipticine hydrochloride exhibits concentration-dependent selective inhibition of p53 protein phosphorylation in Lewis lung carcinoma and SW480 (a human colon cancer cell line) within a range of 0.1 to 100 μM [4]. |
| In vivo | 9-Hydroxyellipticine (5 or 10 mg/kg, ip) induces chromosome clumping and sister chromatid exchange in murine bone marrow cells [1]. |
| Molecular Weight | 298.77 |
| Formula | C17H15ClN2O |
| Cas No. | 52238-35-4 |
| Smiles | Cl.OC1=CC=C2NC3=C(C2=C1)C(=C4C=NC=CC4=C3C)C |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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