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(S,R,S)-AHPC-PEG4-NH2

Name: (S,R,S)-AHPC-PEG4-NH2
Brand: TargetMol
SKU: T15190L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15190LCas No. 2010159-57-4

Alias VHL Ligand-Linker Conjugates 4, VH032-PEG4-NH2, E3 ligase Ligand-Linker Conjugates 7 Free Base

(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.

(S,R,S)-AHPC-PEG4-NH2

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Catalog No. T15190LAlias VHL Ligand-Linker Conjugates 4, VH032-PEG4-NH2, E3 ligase Ligand-Linker Conjugates 7 Free BaseCas No. 2010159-57-4

(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$38	-	In Stock
25 mg	$77	In Stock	In Stock
50 mg	$118	In Stock	In Stock
100 mg	$178	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Appearance:Oil

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.
Synonyms	VHL Ligand-Linker Conjugates 4, VH032-PEG4-NH2, E3 ligase Ligand-Linker Conjugates 7 Free Base

Chemical Properties

Molecular Weight	663.83
Formula	C₃₂H₄₉N₅O₈S
Cas No.	2010159-57-4
Smiles	C([C@@H](NC(COCCOCCOCCOCCN)=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
Relative Density.	1.230 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 153 mg/mL (230.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5064 mL	7.5320 mL	15.0641 mL	75.3205 mL
5 mM	0.3013 mL	1.5064 mL	3.0128 mL	15.0641 mL
10 mM	0.1506 mL	0.7532 mL	1.5064 mL	7.5320 mL
20 mM	0.0753 mL	0.3766 mL	0.7532 mL	3.7660 mL
50 mM	0.0301 mL	0.1506 mL	0.3013 mL	1.5064 mL
100 mM	0.0151 mL	0.0753 mL	0.1506 mL	0.7532 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc