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UNC7242
(Synonyms: UNC-7242, UNC 7242) Copy Product Info
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Synonyms: UNC-7242, UNC 7242
Catalog No. T212943 Copy Product Info
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UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 is utilized in epigenetics research involving chromatin reader domain function, histone mark recognition, and polycomb-associated transcriptional regulation in malignancy-related biological systems.
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| Description | UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 is utilized in epigenetics research involving chromatin reader domain function, histone mark recognition, and polycomb-associated transcriptional regulation in malignancy-related biological systems. |
| Targets & IC50 | PHF19:0.64±0.14 μM (Kd), PHF1:1.13±0.04 μM (Kd) |
| In vitro | Methods：The binding affinity of UNC7242 to Tudor domains of PHF1 and PHF19 was determined. Jurkat N6 cells were treated with 100 μM UNC7242 for 2 hours, and chromatin binding status of PHF19 was observed. Results：The dissociation constant Kd of UNC7242 binding to PHF1 Tudor domain was 1.13±0.04 μM, and 0.64±0.14 μM for PHF19 Tudor domain. This concentration failed to obviously displace chromatin-bound PHF19 in cells [1]. |
| Synonyms | UNC-7242, UNC 7242 |
| Molecular Weight | 376.88 |
| Formula | C19H25ClN4O2 |
| Smiles | COC1=CC2=C(N3CCN(CC4CC4)CCC3)N=C(Cl)N=C2C=C1OC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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Related Tags: UNC7242 chemical structure | UNC7242 in vitro | UNC7242 formula | UNC7242 molecular weight
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