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FD274

Catalog No. T77629 CAS 2641899-38-7

Synonyms: FD 274, FD-274

FD274 is a potent dual PI3K/mTOR inhibitor with inhibitory effects on PI3Kα/β/γ/δ and mTOR, with IC50s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM, respectively. FD274 showed significant antiproliferative activity in AML cell line antiproliferative assays. FD274 exhibited dose-dependent pit tumor growth activity in an HL-60 xenograft model. FD274 has potential for use in acute myeloid leukemia studies.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

FD274, CAS 2641899-38-7

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 195.00
5 mg	Inquiry	$ 430.00
10 mg	Inquiry	$ 650.00
25 mg	Inquiry	$ 1,110.00
50 mg	Inquiry	$ 1,680.00
100 mg	Inquiry	$ 2,540.00
500 mg	Inquiry	$ 5,588.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

mTOR:2.03 nM, PI3Kα:0.65 nM, PI3Kβ:1.57 nM, PI3Kγ:0.42 nM, PI3Kδ:0.65 nM

Synonyms	FD 274, FD-274
Molecular Weight	480.9
Formula	C22H14ClFN6O2S
CAS No.	2641899-38-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

Related compounds with same targets

SKI V GSK251 BQR-695 FD2056 1-Deoxynojirimycin hydrochloride Alismol Inavolisib PI3K/mTOR Inhibitor-14

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FD274 2641899-38-7 PI3K/Akt/mTOR signaling mTOR PI3K FD 274 FD-274 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.