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ITF3756

Name: ITF3756
Brand: TargetMol
SKU: T69735
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69735Cas No. 2247608-27-9

ITF3756 is a selective HDAC6 inhibitor.

ITF3756

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Purity: 97.74%

Catalog No. T69735Cas No. 2247608-27-9

ITF3756 is a selective HDAC6 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	-	In Stock
5 mg	$94	-	In Stock
10 mg	$143	-	In Stock
25 mg	$257	-	In Stock
50 mg	$373	-	In Stock
100 mg	$527	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.74%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

ITF3756 AI Summary

ITF3756 is a potent histone deacetylase (HDAC) inhibitor that shows significant selectivity towards HDAC6, with an IC50 value of 17.0 nM, and selectivity ratios ranging from 51.0 to 236.0 compared to other HDAC isoforms. In vivo studies in C57BL/6 mice have demonstrated its ability to increase levels of acetylated tubulin and acetylated-histone H3. While it exhibits some cytotoxicity in human cell lines with an IC50 greater than 1000.0 nM, its effects on body weight and platelet levels in mice are moderate, showing slight decreases at certain doses. The compound has a half-life of 1.0 hour in CD-1 mice and shows moderate oral bioavailability in mice, rats, and dogs. Additionally, it inhibits CYP3A4 in human liver microsomes. The compound's bioactivity against various HDAC isoforms has been confirmed through fluorescent microplate reader assays, with the most potent inhibition observed against HDAC6, highlighting its high specificity and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

ITF3756 is a selective HDAC6 inhibitor.

Chemical Properties

Molecular Weight	301.32
Formula	C₁₃H₁₁N₅O₂S
Cas No.	2247608-27-9
Smiles	C(N1C(=NN=N1)C2=CC=CS2)C3=CC=C(C(NO)=O)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (182.53 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3187 mL	16.5937 mL	33.1873 mL	165.9365 mL
5 mM	0.6637 mL	3.3187 mL	6.6375 mL	33.1873 mL
10 mM	0.3319 mL	1.6594 mL	3.3187 mL	16.5937 mL
20 mM	0.1659 mL	0.8297 mL	1.6594 mL	8.2968 mL
50 mM	0.0664 mL	0.3319 mL	0.6637 mL	3.3187 mL
100 mM	0.0332 mL	0.1659 mL	0.3319 mL	1.6594 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc