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CUR5g

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Catalog No. T73550Cas No. 1370032-20-4
Alias CUR-5g

CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.

CUR5g

CUR5g

😃Good
Purity: 98.92%
Catalog No. T73550Alias CUR-5gCas No. 1370032-20-4
CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$56In StockIn Stock
5 mg$137In StockIn Stock
10 mg$218In StockIn Stock
25 mg$437In StockIn Stock
50 mg$696In StockIn Stock
100 mg$1,030-In Stock
1 mL x 10 mM (in DMSO)$152In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.92%
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Product Introduction

Bioactivity
Description
CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
In vitro
In A549 cells, CUR5g (at concentrations of 0, 1, 5, 10, 20, and 40 μM; observed at 3, 6, 12, and 24 hours) induces extensive cytoplasmic vacuolization, and the GFP-LC3B signal shifts from diffuse cytosolic staining to a punctate pattern outlining autophagosomes[1].
In vivo
CUR5g (40 mg/kg) and cisplatin (1 mg/kg), administered via the caudal vein every other day for a total of 15 days, were able to retard the growth of xenografted tumors. The combined treatment of CUR5g and cisplatin nearly completely inhibited tumor growth[1].
SynonymsCUR-5g
Chemical Properties
Molecular Weight344.41
FormulaC22H20N2O2
Cas No.1370032-20-4
SmilesC(\C=1C=2C(NC1)=CC=CC2)=C\3/C(=O)\C(=C\C4=CC=C(O)C=C4)\CN(C)C3
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (116.14 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.81 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9035 mL14.5176 mL29.0352 mL145.1758 mL
5 mM0.5807 mL2.9035 mL5.8070 mL29.0352 mL
10 mM0.2904 mL1.4518 mL2.9035 mL14.5176 mL
20 mM0.1452 mL0.7259 mL1.4518 mL7.2588 mL
50 mM0.0581 mL0.2904 mL0.5807 mL2.9035 mL
100 mM0.0290 mL0.1452 mL0.2904 mL1.4518 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

autophagy
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