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CUR5g

Name: CUR5g
Brand: TargetMol
SKU: T73550
Price: 93 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73550Cas No. 1370032-20-4

Alias CUR-5g

CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.

CUR5g

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Purity: 98.92%

Catalog No. T73550Alias CUR-5gCas No. 1370032-20-4

Pack Size	Price	Availability
1 mg	$93	In Stock
5 mg	$228	In Stock
10 mg	$363	In Stock
25 mg	$728	In Stock
50 mg	$1,160	In Stock
100 mg	$1,730	In Stock
1 mL x 10 mM (in DMSO)	$253	In Stock

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Batch Information

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Purity:98.92%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
In vitro	In A549 cells, CUR5g (at concentrations of 0, 1, 5, 10, 20, and 40 μM; observed at 3, 6, 12, and 24 hours) induces extensive cytoplasmic vacuolization, and the GFP-LC3B signal shifts from diffuse cytosolic staining to a punctate pattern outlining autophagosomes[1].
In vivo	CUR5g (40 mg/kg) and cisplatin (1 mg/kg), administered via the caudal vein every other day for a total of 15 days, were able to retard the growth of xenografted tumors. The combined treatment of CUR5g and cisplatin nearly completely inhibited tumor growth[1].
Synonyms	CUR-5g

Chemical Properties

Molecular Weight	344.41
Formula	C₂₂H₂₀N₂O₂
Cas No.	1370032-20-4
Smiles	C(\C=1C=2C(NC1)=CC=CC2)=C\3/C(=O)\C(=C\C4=CC=C(O)C=C4)\CN(C)C3

Storage & Solubility Information

Storage

store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (116.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9035 mL	14.5176 mL	29.0352 mL	145.1758 mL
5 mM	0.5807 mL	2.9035 mL	5.8070 mL	29.0352 mL
10 mM	0.2904 mL	1.4518 mL	2.9035 mL	14.5176 mL
20 mM	0.1452 mL	0.7259 mL	1.4518 mL	7.2588 mL
50 mM	0.0581 mL	0.2904 mL	0.5807 mL	2.9035 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4518 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc