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CUR5g

Name: CUR5g
Brand: TargetMol
SKU: T73550
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T73550Cas No. 1370032-20-4

Alias CUR-5g

CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.

CUR5g

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Purity: 98.92%

Catalog No. T73550Alias CUR-5gCas No. 1370032-20-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	In Stock	In Stock
5 mg	$137	In Stock	In Stock
10 mg	$218	In Stock	In Stock
25 mg	$437	In Stock	In Stock
50 mg	$696	In Stock	In Stock
100 mg	$1,030	-	In Stock
1 mL x 10 mM (in DMSO)	$152	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.92%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
In vitro	In A549 cells, CUR5g (at concentrations of 0, 1, 5, 10, 20, and 40 μM; observed at 3, 6, 12, and 24 hours) induces extensive cytoplasmic vacuolization, and the GFP-LC3B signal shifts from diffuse cytosolic staining to a punctate pattern outlining autophagosomes[1].
In vivo	CUR5g (40 mg/kg) and cisplatin (1 mg/kg), administered via the caudal vein every other day for a total of 15 days, were able to retard the growth of xenografted tumors. The combined treatment of CUR5g and cisplatin nearly completely inhibited tumor growth[1].
Synonyms	CUR-5g

Chemical Properties

Molecular Weight	344.41
Formula	C₂₂H₂₀N₂O₂
Cas No.	1370032-20-4
Smiles	C(\C=1C=2C(NC1)=CC=CC2)=C\3/C(=O)\C(=C\C4=CC=C(O)C=C4)\CN(C)C3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (116.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9035 mL	14.5176 mL	29.0352 mL	145.1758 mL
5 mM	0.5807 mL	2.9035 mL	5.8070 mL	29.0352 mL
10 mM	0.2904 mL	1.4518 mL	2.9035 mL	14.5176 mL
20 mM	0.1452 mL	0.7259 mL	1.4518 mL	7.2588 mL
50 mM	0.0581 mL	0.2904 mL	0.5807 mL	2.9035 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4518 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc