Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CUR5g, a potent autophagy inhibitor, selectively prevents autophagosome degradation in cancer cells by hindering the fusion of autophagosomes with lysosomes. It disrupts the recruitment of STX17 to autophagosomes through a UVRAG-dependent mechanism, thereby impeding autophagosome-lysosome fusion. This inhibition enhances the anticancer efficacy of Cisplatin against A549 cells, demonstrating significant benefits both in vitro and in vivo [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | CUR5g, a potent autophagy inhibitor, selectively prevents autophagosome degradation in cancer cells by hindering the fusion of autophagosomes with lysosomes. It disrupts the recruitment of STX17 to autophagosomes through a UVRAG-dependent mechanism, thereby impeding autophagosome-lysosome fusion. This inhibition enhances the anticancer efficacy of Cisplatin against A549 cells, demonstrating significant benefits both in vitro and in vivo [1]. |
Molecular Weight | 344.41 |
Formula | C22H20N2O2 |
CAS No. | 1370032-20-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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CUR5g 1370032-20-4 inhibitor inhibit