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cyclo(RLsKDK) TFA
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Catalog No. T75998
Alias BK-1361 TFA, BK1361 TFA
Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.
cyclo(RLsKDK) TFA
😃Good
Purity: 98.54%
Catalog No. T75998Alias BK-1361 TFA, BK1361 TFA
Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $899 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.54%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cyclo(RLsKDK) TFA (BK-1361 TFA) is a cyclic peptide and selective ADAM8 metalloproteinase inhibitor, used in research on inflammation and cancer. |
| Targets&IC50 | ADAM8:182 nM |
| In vitro | cyclo(RLsKDK) TFA promoted ADAM8 inhibition and CD23 shedding with IC50 values of 120 nM and 182 nM, respectively. cyclo(RLsKDK) TFA (200 nM,0-12h) increased the activity of pro-ADAM8 [2]. cyclo(RLsKDK) TFA (200 nM/500 nM,12 h) promoted the growth of Panc1_ctrl and Panc1_A8 cells. cyclo(RLsKDK) TFA(500 nM) causes ERK1/2 phosphorylation in Panc1_ctrl and Panc1_A8 cells. [1] |
| In vivo | cyclo(RLsKDK) TFA (10 μg/g once a week for 4 weeks) significantly reduced tumor volume in mice xenografted with Panc1_ctrl and Panc1_A8. [1] |
| Synonyms | BK-1361 TFA, BK1361 TFA |
| Molecular Weight | 841.88 |
| Formula | C33H58F3N11O11 |
| Smiles | CC(C)C[C@H]1C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCN=C(N)N)CCCCN)CC(=O)O)CCCCN)CO.C(=O)(C(F)(F)F)O |
| Sequence | Cyclo(Arg-Leu-{d-Ser}-Lys-Asp-Lys) |
| Sequence Short | Cyclo(RL-{d-Ser}-KDK) |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 80 mg/mL (95.03 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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