Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739.
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Description | Thalidomide-NH-PEG4-Ms is a conjugate that consists of a cereblon ligand based on Thalidomide and a linker molecule, which serves as a ligand-linker moiety for E3 ligase. This conjugate is specifically designed as a degrader for PROTAC BCL-XL, known as XZ739. |
In vitro | XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC 50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1]. |
Molecular Weight | 527.55 |
Formula | C22H29N3O10S |
CAS No. | 2140807-24-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Thalidomide-NH-PEG4-Ms 2140807-24-3 Thalidomide NH PEG4 Ms ThalidomideNHPEG4Ms Thalidomide-NH-PEG-4-Ms inhibitor inhibit