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NSC 23766

Name: NSC 23766
Brand: TargetMol
SKU: T40848
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T40848Cas No. 733767-34-5

Alias NSC23766

NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR)-induced Rac1 activation in neonatal rat cardiomyocytes.

NSC 23766

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Purity: 99.49%

Catalog No. T40848Alias NSC23766Cas No. 733767-34-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$49	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.49%

Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	NSC 23766 is a Rac1 GTPase inhibitor that inhibits Rac1 activation by targeting guanine nucleotide exchange factors (GEFs), while it has no inhibitory effect on the closely related targets Cdc42 and RhoA, affecting the cell cycle and inhibiting cell proliferation in a dose-dependent manner. It also regulates endothelial NO synthase expression and endothelial function, and inhibits platelet aggregation and γ-secretase activity.NSC23766 competitively inhibits M2 muscarinic acetylcholine receptor (M2 mAChR)-induced Rac1 activation in neonatal rat cardiomyocytes.
In vitro	Treatment of oocytes with NSC 23766 (200 μM) increased the percentage of oocytes with abnormal spindle morphology and significantly decreased the expression of p-MAPK protein. [2]
In vivo	Treatment of NOD mice with NSC 23766 (2.5 mg/kg/day, intraperitoneal injection) significantly slowed the onset of spontaneous diabetes in NOD mice and had no significant effect on the growth (body weight) of the mice. [1]
Synonyms	NSC23766

Chemical Properties

Molecular Weight	421.58
Formula	C₂₄H₃₅N₇
Cas No.	733767-34-5
Smiles	N=1C(=NC(=CC1NC=2C=CC=3N=C(C=C(N)C3C2)C)C)NC(C)CCCN(CC)CC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (189.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (7.83 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3720 mL	11.8601 mL	23.7203 mL	118.6015 mL
5 mM	0.4744 mL	2.3720 mL	4.7441 mL	23.7203 mL
10 mM	0.2372 mL	1.1860 mL	2.3720 mL	11.8601 mL
20 mM	0.1186 mL	0.5930 mL	1.1860 mL	5.9301 mL
50 mM	0.0474 mL	0.2372 mL	0.4744 mL	2.3720 mL
100 mM	0.0237 mL	0.1186 mL	0.2372 mL	1.1860 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc