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Devazepide

Name: Devazepide
Brand: TargetMol
SKU: T15101
Rating: 4.5 (1 reviews)

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Catalog No. T15101Cas No. 103420-77-5

Alias MK-329, MK329, L-364,718, L364,718

Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.

Devazepide

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Purity: 99.55%

Catalog No. T15101Alias MK-329, MK329, L-364,718, L364,718Cas No. 103420-77-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$68	5 days	5 days
5 mg	$128	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$152	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.
Targets&IC50	CCK receptor (bovine gallbladder):81 pM, CCK receptor (rat pancreas):45 pM, CCK receptor (guinea pig brain):245 nM
In vivo	Oral gavage administration of Devazepide (4 mg/kg, twice daily) significantly accelerated cholesterol crystal formation, crystal growth until developing into microlithiasis, and promoted gallstone formation in mice [2]. Intraperitoneal injection of Devazepide (0.1–1 mg/kg) exerted opposing regulatory effects on the basal spontaneous activity of mice and the hypokinesia induced by caerulein and apomorphine [3].
Synonyms	MK-329, MK329, L-364,718, L364,718

Chemical Properties

Molecular Weight	408.45
Formula	C₂₅H₂₀N₄O₂
Cas No.	103420-77-5
Smiles	N(C(=O)C1=CC=2C(N1)=CC=CC2)[C@H]3N=C(C=4C(N(C)C3=O)=CC=CC4)C5=CC=CC=C5
Relative Density.	1.31 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (391.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4483 mL	12.2414 mL	24.4828 mL	122.4140 mL
5 mM	0.4897 mL	2.4483 mL	4.8966 mL	24.4828 mL
10 mM	0.2448 mL	1.2241 mL	2.4483 mL	12.2414 mL
20 mM	0.1224 mL	0.6121 mL	1.2241 mL	6.1207 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4483 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2241 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc