Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Devazepide

Name: Devazepide
Brand: TargetMol
SKU: T15101
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T15101Cas No. 103420-77-5

Alias MK-329, MK329, L-364,718, L364,718

Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.

Devazepide

😃Good

Purity: 99.55%

Catalog No. T15101Alias MK-329, MK329, L-364,718, L364,718Cas No. 103420-77-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$68	5 days	5 days
5 mg	$128	7-10 days	7-10 days
1 mL x 10 mM (in DMSO)	$152	7-10 days	7-10 days

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Devazepide is a competitive, selective, orally available non-peptide CCK1 (cholecystokinin 1) receptor antagonist that inhibits bladder cancer cell proliferation and migration while inducing apoptosis and cell cycle arrest.
Targets&IC50	CCK receptor (rat pancreas):45 pM, CCK receptor (guinea pig brain):245 nM, CCK receptor (bovine gallbladder):81 pM
In vivo	Oral gavage administration of Devazepide (4 mg/kg, twice daily) significantly accelerated cholesterol crystal formation, crystal growth until developing into microlithiasis, and promoted gallstone formation in mice [2]. Intraperitoneal injection of Devazepide (0.1–1 mg/kg) exerted opposing regulatory effects on the basal spontaneous activity of mice and the hypokinesia induced by caerulein and apomorphine [3].
Synonyms	MK-329, MK329, L-364,718, L364,718

Chemical Properties

Molecular Weight	408.45
Formula	C₂₅H₂₀N₄O₂
Cas No.	103420-77-5
Smiles	N(C(=O)C1=CC=2C(N1)=CC=CC2)[C@H]3N=C(C=4C(N(C)C3=O)=CC=CC4)C5=CC=CC=C5
Relative Density.	1.31 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 160 mg/mL (391.72 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4483 mL	12.2414 mL	24.4828 mL	122.4140 mL
5 mM	0.4897 mL	2.4483 mL	4.8966 mL	24.4828 mL
10 mM	0.2448 mL	1.2241 mL	2.4483 mL	12.2414 mL
20 mM	0.1224 mL	0.6121 mL	1.2241 mL	6.1207 mL
50 mM	0.0490 mL	0.2448 mL	0.4897 mL	2.4483 mL
100 mM	0.0245 mL	0.1224 mL	0.2448 mL	1.2241 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc