(-)-Indolactam V

Name: (-)-Indolactam V
Brand: TargetMol
SKU: T17299
Rating: 4.5 (1 reviews)

(Synonyms: Indolactam V) Copy Product Info

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Synonyms: Indolactam V

Catalog No. T17299 Copy Product Info

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(-)-Indolactam V, a potent PKC activator, exhibits binding affinities (Kis) of 3.36 nM and 1.03 μM for η-CRD2 and γ-CRD2, respectively, and dissociation constants (Kds) of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), and 213 nM (γ-C1B), also demonstrating antitumor activity.

Cas No. 90365-57-4

Pack Size	Price	USA Stock	Global Stock	Quantity
500 µg	$395	35 days	35 days
1 mg	$748	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Product Introduction

Bioactivity

Description	(-)-Indolactam V, a potent PKC activator, exhibits binding affinities (Kis) of 3.36 nM and 1.03 μM for η-CRD2 and γ-CRD2, respectively, and dissociation constants (Kds) of 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), and 213 nM (γ-C1B), also demonstrating antitumor activity.
Targets & IC50	PKCα-C1A-long:20.8 nM （kd）, PKCα-C1B-long:4000 nM （kd）, PKCγ-CRD2:1030 nM （ki）, PKCβ-C1B:137 nM （kd）, PKCγ-C1A:138 nM （kd）, PKCη-C1B:5.5 nM （kd）, PKCε-C1B:7.7 nM （kd）, PKCθ-C1B:8.7 nM （kd）, PKCη-CRD2:3.36 nM （ki）, PKCε-C1A:4110 nM （kd）, PKCδ-C1A:1900 nM （kd）, PKCγ-C1B:213 nM （kd）, PKCη-C1A:3770 nM （kd）, PKCβ-C1A-long:18.9 nM （kd）, PKCδ-C1B:8.3 nM （kd）
Synonyms	Indolactam V

Chemical Properties

Molecular Weight	301.38
Formula	C₁₇H₂₃N₃O₂
Cas No.	90365-57-4
Smiles	CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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