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SD-436
🥰Excellent
Catalog No. T203395Cas No. 2497585-50-7
Alias SD436
SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.
SD-436
🥰Excellent
Purity: 99.34%
Catalog No. T203395Alias SD436Cas No. 2497585-50-7
SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $993 | In Stock | |
| 5 mg | $2,480 | In Stock | |
| 10 mg | $3,980 | In Stock | |
| 25 mg | $7,670 | In Stock | |
| 50 mg | $9,870 | In Stock |
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Purity:99.34%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SD-436 is a selective and highly efficient STAT3 PROTAC degrader (DC50 = 0.5 μM), with an IC50 of 19 nM for STAT3, significantly higher than for STAT1/4/5/6. SD-436 depletes STAT3 and induces tumour regression in mouse leukaemia and lymphoma xenograft models. |
| Targets&IC50 | STAT3:19 nM, STAT1:270 nM, STAT6:>10 μM, STAT5:>10 μM |
| In vitro | Methods: Human PBMC, SU-DHL-1, and MOLM-16 cell lines were treated with SD-436 (0.1 nM-40 μM, 20 h), and the expression level of STAT3 protein in the cells was detected by Western blot. Results: SD-436 could reduce the level of STAT3 protein in human PBMC, SU-DHL-1, and MOLM-16 cell lines. [1] |
| In vivo | SD-436 (5-25 mg/kg, intravenous) was used to treat mice bearing leukemia and lymphoma xenografts and was found to exhibit antitumor activity in mice. [1] |
| Synonyms | SD436 |
| Molecular Weight | 1248.2 |
| Formula | C58H62F4N9O14PS |
| Cas No. | 2497585-50-7 |
| Smiles | C(#CCCC1CCN(C([C@H](CC2=CC(F)=C(F)C=C2)NC([C@@H](NC(=O)[C@H]3N4[C@](CC3)(CCN(C(OC)=O)C[C@H](NC(=O)C5=CC=6C(S5)=CC=C(C(P(=O)(O)O)(F)F)C6)C4=O)[H])CCC(N)=O)=O)=O)CC1)C7=C8C(C(=O)N(C8)C9C(=O)NC(=O)CC9)=CC=C7 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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