Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 105.00 | |
10 mg | In stock | $ 172.00 | |
25 mg | In stock | $ 372.00 | |
50 mg | In stock | $ 597.00 | |
100 mg | In stock | $ 879.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 118.00 |
Description | MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K4 trimethylation. |
Targets&IC50 | PRDM9:80 nM |
In vitro | After 24 hours of treatment, MRK-740 (3 μM) does not affect the growth of HEK293T cells at IC90, but some toxicity is observed at 10 μM. MRK-740 serves as an equivalent inhibitor of H3K4 methylation in MCF7 cells. In cells, MRK-740 selectively and directly inhibits H3K4 methylation at endogenous PRDM9 target sites[1]. |
Molecular Weight | 464.56 |
Formula | C25H32N6O3 |
CAS No. | 2387510-80-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (64.58 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MRK-740 2387510-80-5 Chromatin/Epigenetic Histone Methyltransferase inhibitor inhibit